Interaksi Metabolisme INH & Rifampisin Menggunakan Hepatosit Tikus

Fasich and Suharjono and Sri Wahyuni and I Ketut Mandikin and Mulja Hadi Santosa (2000) Interaksi Metabolisme INH & Rifampisin Menggunakan Hepatosit Tikus. Majalah Kedokteran Tropis Indonesia, 11 (2). ISSN 0215-8094

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Abstract

Research on the interaction isoniazid metabolism and rifampicin using rat hepatocytes suspension has been done. As the system metabolism. hepatocytes suspension was prepared by perfusion in the calcium binding media containing EDTA, citrate and glycine was used. Treatment at the hepatocytes suspension devided into two groups. One group research on the influence of isoniazid on rifampicin metabolism. Second research on the influence of rifampicin on isoniazid metabolism. Each group devided into five subgroups. Result calculated on the base of variation of rifampicin AUC-value beginning from 0 up to 180 minutes showed that isoniazid wilh concentration 5 µg, 10 µg, 15 µg, and 20 µg, did not influence metabolism of rifampicin (10 µg/ml) as showed by no significant changes of AVC values of rifampicin for α= 0.005 on the otherhand result calculated on the based variation of isoniazid AUC-value beginning from 0 up to 180minutes showed that rifampicin with concentration 5 µg, 10 µg, 15 µg, and 20 µg did influence the mctabolism of isoniazid ( 10 µg/ml) as showed by significant changes of AVC values of isoniazid for α=0.005. Showed that isoniazid mctabolism decrease used as combination of rifampicin

Item Type: Article
Uncontrolled Keywords: Isoniazid rifampicin; metabolism, rat hepatocytes
Subjects: R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Peer Review
Creators:
CreatorsNIM/NIDN
FasichUNSPECIFIED
SuharjonoUNSPECIFIED
Sri WahyuniUNSPECIFIED
I Ketut MandikinUNSPECIFIED
Mulja Hadi SantosaUNSPECIFIED
Depositing User: Ika Rudianto
Date Deposited: 24 Jan 2017 17:39
Last Modified: 24 Jan 2017 17:39
URI: http://repository.unair.ac.id/id/eprint/51726
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