UJI EFEKTIVITAS PEMBERIAN ANTIBIOTIKA AMPISILIN SEBAGAI BENTUK MANIPULASI GUT MICROBIOTA TERHADAP PENURUNAN GULA DARAH TIKUS

ERFA SURYA CHINDI, 011211133124 (2016) UJI EFEKTIVITAS PEMBERIAN ANTIBIOTIKA AMPISILIN SEBAGAI BENTUK MANIPULASI GUT MICROBIOTA TERHADAP PENURUNAN GULA DARAH TIKUS. Skripsi thesis, Universitas Airlangga.

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Abstract

Background: The importance of showing the effectiveness of gut microbiota manipulation in reducing blood glucose concentration. Objective: proving that High Fat Diet and Streptozotocin (HFD+STZ) diabetic rat model will significantly increase blood glucose concentration meanwhile also showing that Gut microbiota manipulation by Antibiotic administration of Ampicillin (20 mg/ kg BW) can reduce blood glucose concentration. Method: Pure Experimental research method by using 18 wistar rat (Rattus norvegicus) divided into 3 groups: Control negative, HFD+STZ without antibiotic administration as control positive and HFD+STZ with antibiotic administration then utilize random glucose test as a parameter. Analysis of variance (ANOVA) was used to prove the difference between each group. The first ANOVA analyze the percentage of the increasing result of Random Glucose Test (RGT) 2 to RGT 1. The second ANOVA analyze the percentage of the decreasing result of Random Glucose Test (RGT) 3 to RGT 2 Results:Significant difference between HFD+STZ diabetic rat model group and negative control group (p value<0.001). Moreover, There is also a very significant difference between HFD+STZ with antibiotic administration group (Group C) and control positive group (Group B) which can be showed by p-value of 0.004. Conclusion: HFD+STZ Diabetic rat model can significantly increase blood glucose concentration of Wistar rat. Moreover, Antibiotic administration of Ampicillin (20 mg/kg body weight) proved to be effective in reduction blood glucose concentration of HFD+STZ Diabetic wistar rat model. Keywords: Gut microbiota, Ampicillin, Diabetic rat model and HFD+STZ

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD. 08-16 Chi u
Uncontrolled Keywords: Gut microbiota, Ampicillin, Diabetic rat model and HFD+STZ
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsEmail
ERFA SURYA CHINDI, 011211133124UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorNurmawati Fatimah, dr., M.Si.UNSPECIFIED
ContributorLina Lukitasari, dr., M.SiUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 30 Jan 2017 02:33
Last Modified: 30 Jan 2017 02:33
URI: http://repository.unair.ac.id/id/eprint/52097
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