ERFA SURYA CHINDI, NIM011211133124 (2016) UJI EFEKTIVITAS PEMBERIAN ANTIBIOTIKA AMPISILIN SEBAGAI BENTUK MANIPULASI GUT MICROBIOTA TERHADAP PENURUNAN GULA DARAH TIKUS. Skripsi thesis, Universitas Airlangga.
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Abstract
Background: The importance of showing the effectiveness of gut microbiota manipulation in reducing blood glucose concentration. Objective: proving that High Fat Diet and Streptozotocin (HFD+STZ) diabetic rat model will significantly increase blood glucose concentration meanwhile also showing that Gut microbiota manipulation by Antibiotic administration of Ampicillin (20 mg/ kg BW) can reduce blood glucose concentration. Method: Pure Experimental research method by using 18 wistar rat (Rattus norvegicus) divided into 3 groups: Control negative, HFD+STZ without antibiotic administration as control positive and HFD+STZ with antibiotic administration then utilize random glucose test as a parameter. Analysis of variance (ANOVA) was used to prove the difference between each group. The first ANOVA analyze the percentage of the increasing result of Random Glucose Test (RGT) 2 to RGT 1. The second ANOVA analyze the percentage of the decreasing result of Random Glucose Test (RGT) 3 to RGT 2 Results:Significant difference between HFD+STZ diabetic rat model group and negative control group (p value<0.001). Moreover, There is also a very significant difference between HFD+STZ with antibiotic administration group (Group C) and control positive group (Group B) which can be showed by p-value of 0.004. Conclusion: HFD+STZ Diabetic rat model can significantly increase blood glucose concentration of Wistar rat. Moreover, Antibiotic administration of Ampicillin (20 mg/kg body weight) proved to be effective in reduction blood glucose concentration of HFD+STZ Diabetic wistar rat model. Keywords: Gut microbiota, Ampicillin, Diabetic rat model and HFD+STZ
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKA KK FK.PD. 08-16 Chi u | |||||||||
| Uncontrolled Keywords: | Gut microbiota, Ampicillin, Diabetic rat model and HFD+STZ | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | |||||||||
| Divisions: | 01. Fakultas Kedokteran | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 30 Jan 2017 02:33 | |||||||||
| Last Modified: | 30 Jan 2017 02:33 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/52097 | |||||||||
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