Zamrotul Izzah, S.Farm., M.Sc., Apt and Gratia, Veronica and Toetik Aryani, Dra. M.Si., Apt and Suharjono, Dr., MS., Apt (2013) Effect of Attapulgite on The Oral Bioavailability of Ciprofloxacin. Indonesian Journal of Clinical Pharmacy, 2 (2). pp. 51-56. ISSN 2252-6218 (Print); 2337-5701 (Online)

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Abstract

This study was aimed to determine the effect of attapulgite on the bioavailability of a single orallyadministered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/ kgBW); (iii) ciprofloxacin (23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49 % and 32 % when administered concomitantly with attapulgite (p < 0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin was markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours

Item Type:	Article
Uncontrolled Keywords:	Attapulgite, bioavailability, ciprofloxacin, drug-drug interaction
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Zamrotul Izzah, S.Farm., M.Sc., Apt UNSPECIFIED Gratia, Veronica UNSPECIFIED Toetik Aryani, Dra. M.Si., Apt UNSPECIFIED Suharjono, Dr., MS., Apt UNSPECIFIED
Depositing User:	Ika Rudianto
Date Deposited:	12 Feb 2017 18:34
Last Modified:	24 Apr 2017 16:51
URI:	http://repository.unair.ac.id/id/eprint/52678
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