The Role of p53 Protein Expression in Retinoblastoma

Soebagjo, Hendrian Dwikoloso and Fatmariyanti, Susy and Lutfi, Delfitri and Aulanni’am and Sumitro, Sutiman Bambang (2016) The Role of p53 Protein Expression in Retinoblastoma. European Journal of Biomedical and Phamnceutical Sciences, 3 (7). pp. 1-7. ISSN 2349-8870

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This study was undertaken to demonstrate the expression of p53 in retinoblastoma. Thirty three retinoblastoma tissue samples of intratumoral retinoblastoma were tested with SDS-PAGE to find the expression of retinoblastoma protein, followed by Western blotting and immunohistochemistry to confirm p53 expression. The electrophoresis examination identified 10 major protein fractions with molecular weight from 103 – 14 kDa. Poorly differentiated retinoblastoma samples revealed 10 protein fractions (molecular weight 103 – 14 kDa) and well differentiated retinoblastoma revealed 9 protein fractions (molecular weight from 97 – 14 kDa). Western blot and immunohistochemistry assay using monoclonal antibody p53 showed that samples are positively expressed p53. No significant correlation was found between p53 expression and differentiation of retinoblastoma (p<0.429, C = 0,214).

Item Type: Article
Uncontrolled Keywords: retinoblastoma, differentiation, p53 expression.
Subjects: R Medicine > RE Ophthalmology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Mata
Peer Review
Soebagjo, Hendrian DwikolosoUNSPECIFIED
Fatmariyanti, SusyUNSPECIFIED
Lutfi, DelfitriUNSPECIFIED
Sumitro, Sutiman BambangUNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 18 Feb 2017 14:31
Last Modified: 18 Feb 2017 14:31
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