PENGARUH PEMBERIAN EKSTRAK JAHE MERAH (Zingiber officinale Roscoe) PADA LAMBUNG MENCIT (Mus musculus) JANTAN YANG MENGALAMI ULKUS PEPTIKUM AKIBAT INDUKSI INDOMETASIN

Katherine Julia Pratiwi, 011311133240 (2016) PENGARUH PEMBERIAN EKSTRAK JAHE MERAH (Zingiber officinale Roscoe) PADA LAMBUNG MENCIT (Mus musculus) JANTAN YANG MENGALAMI ULKUS PEPTIKUM AKIBAT INDUKSI INDOMETASIN. Skripsi thesis, Universitas Airlangga.

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Abstract

Introduction : Zingiber officinale Roscoe has an oil contents of volatile components ( essential oil) and non- volatile components (Oleoresin) which can be used as a drug to treat digestive problems through anti-inflammatory mechanism. The main mechanism of occurrence of peptic ulcer induced by indomethacine is an inflammatory effect due to non-selective COX inhibitor. The purpose of this study is to find out the protective effects of the Zingiber officinale Roscoe usage in reducing the occurence of peptic ulcer. Methods : This study used post test control group design. Randomly selected of 28 male mices were classified into four groups. Group I (Negative Control, received 30 mg/kg bodyweight of indometachine), Group II (Dosage 1, receive 30 mg/Kg bodyweight of indomethacine and Zingiber officinale Roscoe 70 mg/Kg bodyweight), Group III (Dosage 2, receive 30 mg/Kg bodyweight of indomethacine and Zingiber officinale Roscoe 140 mg/Kg bodyweight), and Group IV (Dosage 3, receive 30 mg/Kg bodyweight of indomethacine and Zingiber officinale Roscoe 280 mg/Kg bodyweight). Indomethacine and Zingiber officinale Roscoe was given orally. The parameters measured in this study are the number of macroscopic gastric lesion as a manifestasion of peptic ulcer. Results : the results of this study showed significant differences in the number of lesions among the first group as a negative control group and Group III as a treatment group (F test, p<0,05), and there is no significant difference between treatment groups (II, III, IV) with different doses (F test, p>0,05). Conclusion : Zingiber officinale Roscoe can reduce the occurence of gastric peptic ulcer. Key words : Indometachine, Zingiber officinale Roscoe, Peptic ulcer, Gastric macroscopic lesion

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD.54-16 Pra p
Uncontrolled Keywords: Indometachine, Zingiber officinale Roscoe, Peptic ulcer, Gastric macroscopic lesion
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsEmail
Katherine Julia Pratiwi, 011311133240UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorRoostantia Indrawati, dr., M.Kes, AFKUNSPECIFIED
ContributorEdhi Rianto, dr., MSUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 21 Feb 2017 19:52
Last Modified: 21 Feb 2017 19:52
URI: http://repository.unair.ac.id/id/eprint/53219
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