Role Of Temozomalide in Management of High Grade Glioma

Ugroseno Yudho Bintoro, Siprianus (2014) Role Of Temozomalide in Management of High Grade Glioma. In: Naskah Lengkap Surabaya Hematologi Onkologi Medik Update - Xll (Surabaya HOM-Update XII)). Surabaya Hematologi Onkologi Medik Update - Xll FK Unair, Surabaya, pp. 35-40. ISBN 978 6021871027

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Abstract

Temozolomide is an imidazotetrazine derivative of the alkylating agent with chemical structure, unique pharmacokinetic. Temozolamide is imidazotetrazine genetrasi prodrugs that undergo both spontaneous conversion to the active lorm MTIC which does not require metabolism in the liver. Temozolomide has a small molecular weighl, so that efficient Temozolomide crosses the blood-brain barrier. Temozolomide lncreased survival and an increase in time to progression (TTP). This was without having a statistically significant negative effect on quality of life and with a low incidence of early adverse events. Crade 3/4 haematological toxicity was found in 5 to 14%. ln recurrent high grade gliomas, temozolomide did not increase overall survival but increase time to progression.

Item Type: Book Section
Uncontrolled Keywords: Temozolomide , Glioma
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsEmail
Ugroseno Yudho Bintoro, SiprianusUNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 26 Feb 2017 21:57
Last Modified: 03 Jul 2017 18:53
URI: http://repository.unair.ac.id/id/eprint/53451
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