Gene Mutation Profile in Chronic Myelogenous Leukemia BCR-ABL. Positive Chronic Phase Patients Which not Response to lmatinib Treatment in Dr. Soetomo Teaching Hospital Surabaya lndonesia

Ugroseno Yudho Bintoro, Siprianus (2014) Gene Mutation Profile in Chronic Myelogenous Leukemia BCR-ABL. Positive Chronic Phase Patients Which not Response to lmatinib Treatment in Dr. Soetomo Teaching Hospital Surabaya lndonesia. The Korean Journal of Internal Medicine, 29 (5). p. 29. ISSN 1226-3303

[img] Text (peerreview dan validasi)
peerreview13.Gene Mutation Profi23022017091215.pdf
Restricted to Registered users only

Download (1MB) | Request a copy
[img] Text (fulltext)
53490.pdf
Restricted to Registered users only

Download (414kB) | Request a copy
Official URL: http://www.kjim.org

Abstract

To determine patterns of gene mutations in BCR-ABL tyrosine kinase in chronic myelogenous leukemia BCR-ABL positive chronic phase are not complete molecular response to lmatinib treatment methods: Gene Mutation Analysis has been done in sixteen chronic myelogenous leuki mia patients with BCR-ABL positive chronic phase who are not complete molecular response to lmatinib after 18 months treatment Result: We found C944T gene mutation in 9 (56,25%) patients, T1O52C gen mutation in 16 patient (100%), and T932C gene mutation in 13 patients (81,25%). One Type of Mutation found in one patient, two types of mutations in six patients, and three type mutations in nine patients Conclusion : No siqnificant effect of the C944T mutation and the T932C mutation with a single mutation of the tyrosine kinase drug resistance. Ihere is influence of the T1052C single mutation to tyrosine kinase drug resistance.

Item Type: Article
Uncontrolled Keywords: Gene Mutation;Chronic Myelogenous; Leukemia; BCR-ABL. Positive Chronic Phase Patients lmatinib Treatment in Dr. Soetomo Teaching Hospital Surabaya lndonesia
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM/NIDN
Ugroseno Yudho Bintoro, SiprianusUNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 23 Feb 2017 23:51
Last Modified: 03 Jul 2017 19:01
URI: http://repository.unair.ac.id/id/eprint/53490
Sosial Share:

Actions (login required)

View Item View Item