Correlation between in silico and in vitro Results of 1-(Benzoyloxy)urea and its Derivatives as Potential Anti-Cancer Drugs

Suko Hardjono and Siswandono Siswodihardjo and Purwanto Pramono and Win Darmanto, NIDN. 0016066103 (2017) Correlation between in silico and in vitro Results of 1-(Benzoyloxy)urea and its Derivatives as Potential Anti-Cancer Drugs. Chemistry & Chemical Technology, 11 (1). pp. 19-24. ISSN 1996-4196

[img]
Preview
Image (COVER)
tytulka-180.jpg

Download (32kB) | Preview
[img]
Preview
Text (ABSTRAK)
abstrak_723.pdf

Download (18kB) | Preview
[img]
Preview
Text (FULLTEXT)
jurnal bukti C-04 Chemistry & Chemical Tech Vol-11 No-1 2017.pdf

Download (1MB) | Preview
[img] Text (PEER REVIEW)
Bukti C-04 Prof Siswandono.pdf
Restricted to Registered users only

Download (1MB)
Official URL: http://science2016.lp.edu.ua/sites/default/files/F...

Abstract

1-(Benzoyloxy)urea and its derivatives were synthesized by modified Scotten-Bauman reaction with adding benzoyl chloride or homologs to hydroxyurea in tetrahydrofuran. Structure characterization was conducted based on ultra-violet (UV-VIS) spectrum, infrared (FT-IR), H nucleus magnetic resonance (1H NMR), C nuclear magnetic resonance (13C NMR) and mass spectrometry (MS). In silico test to predict anti-cancer activity of 1-(benzoyloxy)urea and its derivatives in ribonucleotide reductase enzyme (PDB: 2EUD) was done using Molegro Program. The anti-cancer activity test was performed in vitroby using MTT method to HeLa cell lines. In silico test result (Rerank Score) was correlated relative to anti-cancer activity (log1/IC50). There was a significant linear relationship between in vitroand in silico anti-cancer activity.

Item Type: Article
Uncontrolled Keywords: 1-(benzoyloxy)urea, derivatives, in silico test, in vitrotest, rerank score
Subjects: Q Science > QD Chemistry > QD241-441 Organic chemistry
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Peer Review
Creators:
CreatorsNIM/NIDN
Suko HardjonoUNSPECIFIED
Siswandono SiswodihardjoUNSPECIFIED
Purwanto PramonoUNSPECIFIED
Win Darmanto, NIDN. 0016066103UNSPECIFIED
Depositing User: Ika Rudianto
Date Deposited: 14 Mar 2017 16:42
Last Modified: 23 May 2017 15:34
URI: http://repository.unair.ac.id/id/eprint/54434
Sosial Share:

Actions (login required)

View Item View Item