PROFIL PENGGUNAAN ANTITUBERKULOSIS PADA PASIEN AIDS ANAK RAWAT INAP (Penelitian dilakukan di RSUD Dr. Saiful Anwar Malang)

MAXIMA ANTONIA BOKILIA, 051211131065 (2016) PROFIL PENGGUNAAN ANTITUBERKULOSIS PADA PASIEN AIDS ANAK RAWAT INAP (Penelitian dilakukan di RSUD Dr. Saiful Anwar Malang). Skripsi thesis, Universitas Airlangga.

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Abstract

Backgrounds: People with AIDS have an increased risk of developing various bacterial infection such as Mycobacterium tuberculosis. Children with AIDS have a better oppurtunity to TB relapse than children who are not with AIDS. The appropriate management of HIV-associated TB in children remains extremely challenging due to diagnostic difficulties, multidrug resistant, the overlapping side effect profiles of anti-TB and ARV, the complexity of drug-drug interactions and IRIS after initiation of ARV. Objective: To analyze the profile of antituberculosis drugs used in tuberculosis infection with AIDS and to identify drug related problems (DRPs) of antituberculosis drug. Method: It was a retrospective study during period January 2013 to December 2015 in children with AIDS ages 0 to 14 years receiving anti tuberculosis. Result and Discussion: Dose antituberculosis in intensive phase is FDC (R 75 mg, H 50 mg, and Z 150 mg) (1 x 1, 2, 3 and 4 tabs) po, FDC (R 37 mg, H 37 mg, Z 111 mg) 1x¾ tab and FDC (R 90 mg, 60 mg H, Z 180 mg) 1x1,5 tab. Ethambutol dose is (1 x 110, 130, 200 and 400 mg) po. HES dose is H 1x145 mg, 1x360 mg E and S 1x300 mg IM. Doses intermediate phase is FDC (R 75 mg and H 50 mg. The problems that occur related to drugs is a side effect of H which causes numbness or tingling of hands and feet, RHZ cause hepatotoxicity and drug interactions of potential antituberculosis (R) and the anti-retroviral (evavirenz, nevirapine, zidovudine). Conclusion : Antituberculosis drugs use in children with AIDS were isoniazid, rifampicin, pyrazinamide, and ethambutol in combination. Route of administration of anti tuberculosis RHZE by oral and S by intramuscular. The dose in children were adjusted to the weight of patient. Keywords: Anti tuberculosis, Children with HIV, Tuberculosis

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK. 23-16 Bok p
Uncontrolled Keywords: Anti tuberculosis, Children with HIV, Tuberculosis
Subjects: R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
R Medicine > RM Therapeutics. Pharmacology
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
MAXIMA ANTONIA BOKILIA, 051211131065UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDidik Hasmono, Drs., Apt., MS.UNSPECIFIED
ContributorJainuri Erik Pratama, M. Farm. Klin, AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 19 Mar 2017 17:41
Last Modified: 19 Mar 2017 17:41
URI: http://repository.unair.ac.id/id/eprint/54851
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