AKTIVITAS ANTIMALARIA IN VIVO TABLET FRAKSI ETIL ASETAT-96 DAN TABLET FRAKSI ETIL ASETAT-70 DARI TANAMAN SAMBILOTO (ANDROGRAPHIS PANICULATA NEES) PADA MENCIT TERINFEKSI PLASMODIUM BERGHEI

DWI AYU FITRIANINGTYAS, 051211132087 (2016) AKTIVITAS ANTIMALARIA IN VIVO TABLET FRAKSI ETIL ASETAT-96 DAN TABLET FRAKSI ETIL ASETAT-70 DARI TANAMAN SAMBILOTO (ANDROGRAPHIS PANICULATA NEES) PADA MENCIT TERINFEKSI PLASMODIUM BERGHEI. Skripsi thesis, Universitas Airlangga.

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Abstract

Andrographis paniculata Nees has been effectively used for antimalarial. Phytopharmaceutical product of Ethyl Acetate fraction of A. paniculata has been developed, named EA-70 and EA-96 tablet. In vivo antimalarial assay was done using Peter’s 4 days suppressive test. Each tablet administered twice a day for four days at a dose 6.25; 12.5; 25; and 50 mg andrographolide/kg BW per oral. Thin films were made from the tail blood of each mouse for seven days treatment (H0 – H6). Antimalarial activity measurement was conducted using microscopic by counting the number of parasitized erythrocytes out of 1000 normal erythrocytes in random fields of the microscope. This results shows that antimalarial activity of EA-70 tablet of A. paniculata has ED50 9,195 mg/kg BW, while EA-96 tablet of A. paniculata has ED50 5,949 mg/kg BW. Mean survival time of EA-70 and EA-96 tablet are more than 12 days. In conclusion, EA-96 tablet more effective for antimalarial than EA-70 tablet. Keywords: Andrographis paniculata Ness; tablets; in vivo antimalarial activity; Plasmodium berghei; Ethyl Acetate fraction; inhibition of parasite’s growth, ED50

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT. 32-16 Fit a.pdf
Uncontrolled Keywords: Andrographis paniculata Ness; tablets; in vivo antimalarial activity; Plasmodium berghei; Ethyl Acetate fraction; inhibition of parasite’s growth, ED50
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
DWI AYU FITRIANINGTYAS, 051211132087UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorAty Widyawaruyanti, Dr., MSi.UNSPECIFIED
ContributorAchmad Fuad Hafid, Dr., MS.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 02 Apr 2017 23:01
Last Modified: 02 Apr 2017 23:01
URI: http://repository.unair.ac.id/id/eprint/55700
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