DWI AYU FITRIANINGTYAS, 051211132087 (2016) AKTIVITAS ANTIMALARIA IN VIVO TABLET FRAKSI ETIL ASETAT-96 DAN TABLET FRAKSI ETIL ASETAT-70 DARI TANAMAN SAMBILOTO (ANDROGRAPHIS PANICULATA NEES) PADA MENCIT TERINFEKSI PLASMODIUM BERGHEI. Skripsi thesis, Universitas Airlangga.

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Abstract

Andrographis paniculata Nees has been effectively used for antimalarial. Phytopharmaceutical product of Ethyl Acetate fraction of A. paniculata has been developed, named EA-70 and EA-96 tablet. In vivo antimalarial assay was done using Peter’s 4 days suppressive test. Each tablet administered twice a day for four days at a dose 6.25; 12.5; 25; and 50 mg andrographolide/kg BW per oral. Thin films were made from the tail blood of each mouse for seven days treatment (H0 – H6). Antimalarial activity measurement was conducted using microscopic by counting the number of parasitized erythrocytes out of 1000 normal erythrocytes in random fields of the microscope. This results shows that antimalarial activity of EA-70 tablet of A. paniculata has ED50 9,195 mg/kg BW, while EA-96 tablet of A. paniculata has ED50 5,949 mg/kg BW. Mean survival time of EA-70 and EA-96 tablet are more than 12 days. In conclusion, EA-96 tablet more effective for antimalarial than EA-70 tablet. Keywords: Andrographis paniculata Ness; tablets; in vivo antimalarial activity; Plasmodium berghei; Ethyl Acetate fraction; inhibition of parasite’s growth, ED50

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