HUBUNGAN ANTARA EKSPRESI INTERLEUKIN 17 DENGAN DESTRUKSI TULANG PADA OTITIS MEDIA SUPURATIF KRONIK TANPA KOLESTEATOMA

Faizal Rachman, NIM011080501 (2016) HUBUNGAN ANTARA EKSPRESI INTERLEUKIN 17 DENGAN DESTRUKSI TULANG PADA OTITIS MEDIA SUPURATIF KRONIK TANPA KOLESTEATOMA. Thesis thesis, Universitas Airlangga.

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Abstract

Objective : to explain the correlation between IL-17 expression in granulation tissue with bone erosion in chronic suppurative otitis media (CSOM) witout cholesteatoma Design of study : cross sectional Method : We performed prospective collection of granulation tissue during mastoidectomy from CSOM without cholesteatoma patient. The tissue samples divided into two groups, with and without bone erosion. All tissues group processed for all samples were then IL-17 examined with mouse monoclonal antibody anti human IL-17 stated in Intensity Distribution Score (IDS). The expression of IL-17 categorized strong intensity, moderate intensity, weak intensity and negative. Strong intensity if IDS about 276.00 – 300, moderate intensity if IDS about 151.00 – 275.99, weak intensity if IDS about 76.00 – 150.99 and IL-17 negative if IDS about 0-76.99. Result : There were 18 samples, 4 with bone erosion and 14 without bone erosion. Expression of IL-17 in the granulation tissue with bone erosion obtained IL-17 moderate intensity were as many as 3 (75%) tissues and IL-17 weak intensity were as many as 1 (25%) tissues. Expression of IL-17 in the granulation tissue without bone erosion obtained IL-17 negative were as many as 6 (42,86%) tissues and IL-17 weak intensity were as many as 8 (57,14%) tissues. Statistical analysis using the Mann-Whitney test p value = 0.005. That means there were significant correlation between IL-17 expression and bone erosion in CSOM without cholesteatoma patients (p < 0.05). Conclusion : there were correlation between IL-17 expression and bone erosion in CSOM without cholesteatoma patients in CSOM patients

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS THT 05-16 Rac h
Uncontrolled Keywords: Chronic suppurative otitis media without cholesteatoma, bone erosion, destruction, granulation tissue, interleukin 17
Subjects: R Medicine > RF Otorhinolaryngology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit THT
Creators:
CreatorsNIM/NIDN
Faizal Rachman, NIM011080501NIM011080501
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTitiek H Ahadiah, dr., Sp.T.H.T.K.L (K)UNSPECIFIED
ContributorSri Herawati J, Prof. dr., Sp.T.H.T.K.L (K)UNSPECIFIED
Depositing User: sukartini sukartini
Date Deposited: 04 Apr 2017 00:03
Last Modified: 04 Apr 2017 00:03
URI: http://repository.unair.ac.id/id/eprint/55825
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