FAUZIAH RAHMAWATI, 051211131022
(2016)
SINTESIS SENYAWA ASAM 2-(4-KLOROBENZOILOKSI)-5-METOKSI BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus).
Skripsi thesis, Universitas Airlangga.
Abstract
SYNTHESIS AND ANALGESIC ACTIVITY TEST OF 2-(4-CHLOROBENZOYLOXY)-5-METHOXY BENZOIC ACID IN MICE (Mus musculus)
Fauziah Rahmawati
Molecular modification is a method that can be done to obtain new compound with greater activity. A salisilic acid derivative, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid was synthesized and tested for analgesic activities. Synthesis of this compound based on esterification reaction by Schotten-Baumann. Its purity was screened by melting point test and Thin Layer Chromatography. UV-Vis Spectrophotometry, Infrared Spectrophotometry, and H-NMR Spectrometry used for confirming the structure of the new compound. In writhing test method, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid was comparing to the standart reference drug, acetyl salicylic acid at equidose and also the control (CMC-Na suspension 0,5%). One way ANOVA showed that there was significant difference from the frequency of writhing in mice between groups of new compound, acetyl salicylic acid, and the control. Efficiency dose (ED50) of 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid is 62,52 mg/kg body weight while Asetosal is 80,28 mg/kg body weight. It showed that 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid has higher analgesic activity than acetyl salicylic acid.
Keyword: synthesis, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid, analgesic activity, Efficiency dose (ED50)
Actions (login required)
 |
View Item |
