SINTESIS SENYAWA ASAM 2-(4-KLOROBENZOILOKSI)-5-METOKSI BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus)

FAUZIAH RAHMAWATI, 051211131022 (2016) SINTESIS SENYAWA ASAM 2-(4-KLOROBENZOILOKSI)-5-METOKSI BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus). Skripsi thesis, Universitas Airlangga.

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Official URL: http://lib.unair.ac.id

Abstract

SYNTHESIS AND ANALGESIC ACTIVITY TEST OF 2-(4-CHLOROBENZOYLOXY)-5-METHOXY BENZOIC ACID IN MICE (Mus musculus) Fauziah Rahmawati Molecular modification is a method that can be done to obtain new compound with greater activity. A salisilic acid derivative, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid was synthesized and tested for analgesic activities. Synthesis of this compound based on esterification reaction by Schotten-Baumann. Its purity was screened by melting point test and Thin Layer Chromatography. UV-Vis Spectrophotometry, Infrared Spectrophotometry, and H-NMR Spectrometry used for confirming the structure of the new compound. In writhing test method, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid was comparing to the standart reference drug, acetyl salicylic acid at equidose and also the control (CMC-Na suspension 0,5%). One way ANOVA showed that there was significant difference from the frequency of writhing in mice between groups of new compound, acetyl salicylic acid, and the control. Efficiency dose (ED50) of 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid is 62,52 mg/kg body weight while Asetosal is 80,28 mg/kg body weight. It showed that 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid has higher analgesic activity than acetyl salicylic acid. Keyword: synthesis, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid, analgesic activity, Efficiency dose (ED50)

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. KF. 11-16 Rah s
Uncontrolled Keywords: synthesis, 2-(4-chlorobenzoyloxy)-5-methoxy benzoic acid, analgesic activity, Efficiency dose (ED50)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsEmail
FAUZIAH RAHMAWATI, 051211131022UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorBambang Tri Purwanto, Dr., Apt.,MSUNSPECIFIED
ContributorPurwanto, Prof. Dr. H., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 06 Apr 2017 21:41
Last Modified: 05 Sep 2017 20:03
URI: http://repository.unair.ac.id/id/eprint/56106
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