PUJI FAUZIAH, 051211131025 (2016) PENGARUH GUGUS METOKSI TERHADAP PERSENTASE HASIL SINTESIS KHALKON DAN TURUNANNYA MENGGUNAKAN IRADIASI GELOMBANG MIKRO. Skripsi thesis, Universitas Airlangga.

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Abstract

THE INFLUENCE OF METHOXY GROUP ON SYNTHESIS CHALCONE AND ITS DERIVATE USING MICROWAVE Puji Fauziah The aim of this research is to determine the influence of methoxy group on synthesis chalcone, 4-methoxychalcone, 2,4-dimethoxychalcone, and 2,4,4’-trimethoxychalcone by comparing the yields of synthesis. Chalcone, 4-methoxychalcone, 2,4-dimethoxychalcone, and 2,4,4’- trimethoxychalcone were synthesized from benzaldehyde or 4- methoxybenzaldehyde and acetophenone or 2,4-dimethoxyacetophenone through Claisen Schmidt aldol condensation with catalyst NaOH and etanol as solvent. The synthesis was carried under microwave irradiation with the same condition and the structured were confirmed by UV-Vis Spectrophotometry, IR Spectrophotometry, and 1H-NMR Spectrophotometry. The synthesis of chalcone and its derivate produce pale yellow crystal and the yield of chalcone is 72 ± 1,4%, the yield of 4- methoxychalcone is 90 ± 1.69%, the yield of 2,4-dimethoxychalcone is 73 ± 2.74% while synthesis of 2,4,4’-trimethoxychalcone was obtained 89 ± 1.17% yield. It can be conclude that methoxy group enhance the reactivity of aromatic ring of benzaldehyde which gave influence on the yields of product. Keywords: synthesis, chalcone, 4-methoxychalcone, 2,4- dimethoxychalcone, 2,4,4’-trimethoxychalcone, Claisen Schmidt aldol condensation, methoxy group, microwave.

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