OPTIMASI PREPARASI SAMPEL DAN VALIDASI METODE KCKT UNTUK PENETAPAN KADAR 1,3-DIMETILOL-5,5-DIMETIL HIDANTOIN DALAM SEDIAAN KRIM

NURUL MAGHFIROH, 051211133091 (2016) OPTIMASI PREPARASI SAMPEL DAN VALIDASI METODE KCKT UNTUK PENETAPAN KADAR 1,3-DIMETILOL-5,5-DIMETIL HIDANTOIN DALAM SEDIAAN KRIM. Skripsi thesis, Universitas Airlangga.

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Abstract

OPTIMATION IN SAMPLE PREPARATION AND VALIDATION OF HPLC METHOD FOR DETERMINATION 1,3-DIMETHYLOL-5,5-DIMETHYL HYDANTOIN IN CREAM PRODUCT Nurul maghfiroh An High performance Liquid Chromatography (HPLC) method has been validated for determination of 1,3-dimethylol-5,5-dimethyl hydantoin (DMDM hydantoin) as preservative in cream product. The condition of HPLC used ODS column (particle size 5μm , i.d. 4.6 mm x 150 mm) with flow rate 1 mL / minute, and detected by Diode Array Detector (λ= 220 nm). The proposed method showed good separation, generating symmetrical peaks with resolution of 1.8. Correlation coefficient of 1,3- dimethylol-5,5-dimethyl hydantoin was 0.999 while relative process standard deviation of the function (Vxo) were 0.0467 %. The average recovery of DMDM hydantoin was 99.85 ± 1.8, and the precision of DMDM hydantoin was 0.56 %. The HPLC method is suitable for the analysis of DMDM hydantoin in sunscreen cream products. Keywords: HPLC, DMDM hydantoin, Validation Method, Sunscreen Cream, Cosmetics

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. KF. 43-16 Mag o
Uncontrolled Keywords: HPLC, DMDM hydantoin, Validation Method, Sunscreen Cream, Cosmetics
Subjects: R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
NURUL MAGHFIROH, 051211133091UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorM. Yuwono, Prof. Dr. rer. nat. H., Ms., AptUNSPECIFIED
ContributorAmirudin Prawita, Prof. Dr. H., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 10 Apr 2017 17:27
Last Modified: 10 Apr 2017 17:27
URI: http://repository.unair.ac.id/id/eprint/56228
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