A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics

Eiby, Yvonne A and Wright, Layne L. and Kalanjati, Viscasari P. and Miller, Stephanie M. and Miller, Stella M. (2013) A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics. Plos One, 7 (8). pp. 1-8. ISSN e68763

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Official URL: http://journals.plos.org/plosone/article?id=10.137...

Abstract

Background Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages. Methods Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols. Results Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability. Conclusion The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes.

Item Type: Article
Uncontrolled Keywords: A pig Model, Preterm Neonate, Anthropometric
Subjects: R Medicine > RZ Other systems of medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Anatomi Histologi
Creators:
CreatorsEmail
Eiby, Yvonne AUNSPECIFIED
Wright, Layne L.UNSPECIFIED
Kalanjati, Viscasari P.UNSPECIFIED
Miller, Stephanie M.UNSPECIFIED
Miller, Stella M.UNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 16 Apr 2017 17:16
Last Modified: 16 Apr 2017 17:16
URI: http://repository.unair.ac.id/id/eprint/56387
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