In vivo antimalarial activity of Andrographis paniculata Tablets

Achmad, Fuad Hafid and Aty, Widyawaruyanti and Muhammad, Asrory and Wiwied Ekasari, NIDN. 0022016902 and Dwi, Setiawan and Achmad, Radjaram and Lidya, Tumewu (2014) In vivo antimalarial activity of Andrographis paniculata Tablets. Procedia Chemistry, 13. pp. 101-104. ISSN 1876-6196

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Abstract

The formulation of three phytopharmaceutical products of Andrographispaniculata fractions (AP fraction A and B) containing diterpene lactones as an active substance were developed and their antimalarial activities against Plasmodium bergheihas been examined. In vivo antimalarial assay on P. berghei infected mice was carried out by oral administration,twice a dayfor four consecutive days of the AP fractions product, which were Tablet I: wet granulated formula of AP fraction A; Tablet II: wet granulated formula of AP fraction B; Tablet III: solid dispersion formula of AP fraction B.. The results revealed that three phytopharmaceutical products of A.paniculata were inhibited parasite's growth with inhibition range of 70.15% to 80.35%. There was no significant difference of antimalarial activities between Tablet II and III, meanwhile there was significant difference among Tablet I with Tablet II and Tablet III.It was concluded that antimalarial activity depending on raw material form of A. paniculata active substance.

Item Type: Article
Uncontrolled Keywords: Andrographis paniculata Ness;tablets;in vivo antimalarial activity;Plasmodium berghei; inhibition of parasite’s growth
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
Achmad, Fuad Hafidachmadfuad@ff.unair.ac.id
Aty, Widyawaruyantiaty-w@ff.unair.ac.id
Muhammad, AsroryUNSPECIFIED
Wiwied Ekasari, NIDN. 0022016902wiwied-e@ff.unair.ac.id
Dwi, Setiawandwisetyawan-90@ff.unair.ac.id
Achmad, RadjaramUNSPECIFIED
Lidya, TumewuUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 08 May 2017 21:29
Last Modified: 08 May 2017 21:29
URI: http://repository.unair.ac.id/id/eprint/56565
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