Hariadini AL and Aryani T and Suharjono (2013) Sucralfate Suspension Reduced Absorption of Oral Ciprofloxacin Hydrochloride in Rabbits. International Journal for Pharmaceutical Research Scholars, 2 (I-3). pp. 202-209. ISSN 2277-7873

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Abstract

One of the most frequent side effects due to the use of ciprofloxacin is a gastrointestinal disorder. Generally, in order to overcome the side effects of the Gastro Intestinal Track (GIT), the drug is given after meals (provided 15-30 minutes after meals). Unfortunately the present of food in gaster can significantly decrease maximum concentration (Cmax) of ciprofloxacin. The aim of this study was to determine the effect of sucralfate suspension that containing alumunium (Al3+) on the absorption of oral ciprofloxacin HCl. The effects of 0.47 mL/kg body weight doses of sucralfate suspension which is containing polyvalent cations, aluminum sucrose octa sulfate on the absorption of oral ciprofloxacin HCl before a single 23 mg/kg body weight doses were investigated in 6 rabbit subjects, randomized, cross over and single blind study. The 6 rabbits were enrolled in two studies. Each subject got single ciprofloxacin HCl administration as a control treatment. Treatments that were evaluated included the administration of sucralfate with single dose of ciprofloxacin HCl concomitantly (treatment 1) and the administration of sucralfate 2 hours before ciprofloxacin HCl administration (treatment 2). The absorption parameters of ciprofloxacin HCl were determined by spectrofluorometric method using time to reach maximum concentration (tmax), Cmax and area under curve (AUC) parameters. In control treatment, the average value of Cmax, tmax, and AUC0-360 were 1.34 µg/mL ± 26.15%, 160.78 minutes ± 5.85% and 337.06 µg minutes/mL ± 14.40%. In treatment 1, the average value of Cmax, tmax, and AUC0-360 were 0.68 µg/mL ± 15.49%, 420.66 minutes ± 25.49% and 277.13 µg.minutes/mL ± 12.25%, and in treatment 2 were 0.95 µg/mL ± 18.54%, 284.93 minutes ± 15.44% and 309.75 µg.minutes/mL ± 11.71%. Statistical analysis used in this study was one-sided paired t test (α = 0.05). On the basis of these findings, ciprofloxacin HCl and sucralfate should not be administered concomitantly, but normal kinetics are restored by administering the drug 2 hours before ciprofloxacin HCl. Andrographis paniculata extract suppressed cancer cell growth by decreased cell proliferation and increased apoptosis.

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