The effect of adding zinc to vitamin A on IGF-1, bone age and lineargrowth in stunted children

Merryana, Adriani and Bambang, Wirjatmadi (2014) The effect of adding zinc to vitamin A on IGF-1, bone age and lineargrowth in stunted children. Journal of Trace Elements in Medicine and Biology, 28 (4). pp. 431-435.

[img] Text (Peer Review)
Peer Riview 15-.pdf
Restricted to Registered users only

Download (420kB) | Request a copy
[img] Text (Full Text)
15.pdf
Restricted to Registered users only

Download (433kB) | Request a copy
Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

A randomized, double-blind, placebo controlled trial of a single dose of 200,000 I.U. of vitamin A with daily zinc supplementation was conducted with children in Mojo village, Surabaya City. Children aged 48 to 60 months were randomized to receive a single dose of 200,000 I.U. of vitamin A plus zinc sulfate (n = 12)or a single dose of 200,000 I.U. of vitamin A (n = 12) plus placebo six days a week for six months. Children were evaluated weekly for nutrient intake and for IGF-1, C-reactive protein levels, gamma globulin levels,serum zinc, serum retinol, bone age and the index height for age at six months.At the end of the study, there was a significant increase in the serum retinol level (p < 0.03), serum zinc level (p < 0.03), IGF-1 hormone (p < 0.04) and Z-score height for age (p < 0.001), bone age (p < 0.01),and gamma globulin level (p < 0.04) and a significant decrease in the amount of infection /inflammation measured by CRP level (p < 0.001). There was also a significant correlation between CRP level and height for age (p < 0.01), and between gamma level and height for age (p < 0.01).These results suggest that combined vitamin A and zinc supplementation reduces the risk of infection and increases linear growth among hildren, and thus may play a key role in controlling infection and stunted growth for children under five years old

Item Type: Article
Uncontrolled Keywords: Zinc and vitamin A supplementation on CRP Gamma globulin IGF-1 Bone age and linear growth (H/A) Stunting
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
T Technology > TX Home economics > TX341-641 Nutrition. Foods and food supply
Divisions: 10. Fakultas Kesehatan Masyarakat > Gizi Kesehatan
Creators:
CreatorsNIM/NIDN
Merryana, AdrianiUNSPECIFIED
Bambang, WirjatmadiUNSPECIFIED
Depositing User: Tn Chusnul Chuluq
Date Deposited: 04 May 2017 23:13
Last Modified: 04 May 2017 23:13
URI: http://repository.unair.ac.id/id/eprint/56941
Sosial Share:

Actions (login required)

View Item View Item