PERBANDINGAN JUMLAH LAPISAN EPITEL KORNEA PASCA PEMBERIAN TIMOLOL 0.5% DENGAN DAN TANPA PRESERVATIVE BENZALKONIUM CHLORIDE 0.01% (Studi Eksperimental pada Oryctolagus cuniculus)

DIMAS SETYA ADINUGRAHA, 011080104 (2016) PERBANDINGAN JUMLAH LAPISAN EPITEL KORNEA PASCA PEMBERIAN TIMOLOL 0.5% DENGAN DAN TANPA PRESERVATIVE BENZALKONIUM CHLORIDE 0.01% (Studi Eksperimental pada Oryctolagus cuniculus). Thesis thesis, Universitas Airlangga.

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Abstract

Objective: to compare the amount of corneal epithelial layers after topical timolol 0.50% administration with and without BAC 0.01% as preservative on rabbit’s (Oryctolagus cuniculus) cornea for 14 days. Method: this is an experimental study on 16 eyes of 8 healthy white male rabbit (Oryctolagus cuniculus) weighing between 2.5 – 3 kgs, separated into two groups, group 1 with 8 eyes received 2 drops of BAC preserved timolol 0.50% daily for 14 days. And group 2 with 8 eyes received 2 drops of unpreserved timolol daily for 14 days. At the end of the study all groups was sacrified, dissected, and processed for histological studies. One additional rabbit without any exposure was sacrificed as a control. Result: there were 7 evaluable rabbit by the 14th days of the experiment (14 eyes). Corneal histopathology examination was performed on the 14th day after drug exposure, the mean corneal epithel cell layer was 3 layer (2.71) on sample exposed to timolol 0.50% eyedrop containing BAC 0.001% preservative, and 6 layers (5.86) on sample exposed to timolol 0.50% eyedrop without preservative. Whereas the amount of normal epithel cell layer in rabbit that did not received any drug exposure was 6 layers. Conclusions: exposure to BAC led to rabbit’s corneal degeneration, corneal sections of group 1 revealed an irregular surface together with desquamation of some surface epithelial cells, it showed thinning of the epithelium that became 3 layers thick. Whereas on group 2 shows no differences compared to control (6 layers). Keyword : Timolol, benzalkonium chloride, corneal epithelial layer

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS. IKM. 11-16 Adi p
Uncontrolled Keywords: Timolol, benzalkonium chloride, corneal epithelial layer
Subjects: R Medicine > RE Ophthalmology
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsEmail
DIMAS SETYA ADINUGRAHA, 011080104UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorEddyanto, dr., SpM (K)UNSPECIFIED
ContributorSuparman, dr., SpPA (K)UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 08 May 2017 22:51
Last Modified: 08 May 2017 22:51
URI: http://repository.unair.ac.id/id/eprint/57276
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