EFEKTIFITAS KETOPROFEN SUPPOSITORIA SEBAGAI PREEMPTIVE ANALGESIA TERHADAP NYERI POSTOPERATIF PADA PASIEN YANG MENJALANI OPERASI ELEKTIF DENGAN GENERAL ANESTESI

Lupi Lestari, dr (2016) EFEKTIFITAS KETOPROFEN SUPPOSITORIA SEBAGAI PREEMPTIVE ANALGESIA TERHADAP NYERI POSTOPERATIF PADA PASIEN YANG MENJALANI OPERASI ELEKTIF DENGAN GENERAL ANESTESI. Thesis thesis, Universitas Airlangga.

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Abstract

Background : Effective postoperative pain management provides improved patient comfort and satisfaction, earlier mobilization, fewer pulmonary and cardiac compilcations, reduced risk deep vein thrombosis, faster recovery , and reduced cost of care. Preemptive analgesia, initiated before the surgical procedure to prevent pain in the early postoperative period has the potential to be more effective than a similar analgesic treatment initiated after surgery. As a part of the multimodal analgesia, the use of NSAIDs should always be considered for acut postoperative pain management. NSAIDs can be used preoperatively as a part of preemptive regimen and for postoperative pain control to increase the efficacy of opioids and reduce its side effect. Objective : To compare the effect of preemptive analgesia with postoperative analgesia using ketoprofen suppositoria in patients undergoing operations with general anesthesia (with postoperative expected pain moderate to severe) Methods : In this randomized, following surgery with general anesthesia, 60 patients, aging 18-65 years, were assigned to receive either morphine 0,1 mg/ kg with ketoprofen suppositoria 100mg (BW ≤ 50kg) and 200 mg (BW > 50 kg) after induction (n=30) and morphine 0,1 mg/kg without any preemptive analgesia (n=30). Intensity of pain, measured with Numeric Rating Scale (NRS) or Wong Baker Faces Pain Scale, was the variable studied at different postoperative times (30 min, 60 min, 120 min, 2-6 h, 6- 12 h). The total amount of rescue analgetics (fentanyl) and side effect were another variable of the study. Results : It was found that ketoprofen suppositoria as preemptive analgesia administrations can reduce postoperative pain. Numeric Rating Scale was significant lower in ketoprofen group compared to control group (p < 0,05) at 30 min, 60 min, 120 min , 2-6 h, 6- 12 h. The amount of postoperative analgesics needed in recovery room was significant different among both of groups (p< 0,05). Conclusion : Preemptive analgesia in patients who underwent operations with general anesthesia with ketoprofen suppositoria was effective in blocking noxious stimuli and central sensitization, with subsequent prevention of acute postoperative pain Keywords : Postoperative analgesia, general anesthesia, ketoprofen suppositoria, preemptive analgesia

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS. AR. 19-16 Les e
Uncontrolled Keywords: Postoperative analgesia, general anesthesia, ketoprofen suppositoria, preemptive analgesia
Subjects: R Medicine > RD Surgery
Divisions: 01. Fakultas Kedokteran > Anestesiologi dan Reanimasi
Creators:
CreatorsNIM/NIDN
Lupi Lestari, drUNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorElizeus Hanindito, Dr. dr., SpAn, KIC, KAPUNSPECIFIED
ContributorArie Utariani, Dr.dr., SpAn, KAPUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 09 May 2017 23:16
Last Modified: 09 May 2017 23:16
URI: http://repository.unair.ac.id/id/eprint/57330
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