PENGARUH JUMLAH CaCl2 TERHADAP KARAKTERISASI FISIK DARI NANOKRISTAL ANDROGRAFOLID-KARBOKSIMETIL KITOSAN TERSAMBUNG SILANG (Dibuat Dengan Metode Penggilingan Basah)

RENISA AZALIA, 051211132094 (2016) PENGARUH JUMLAH CaCl2 TERHADAP KARAKTERISASI FISIK DARI NANOKRISTAL ANDROGRAFOLID-KARBOKSIMETIL KITOSAN TERSAMBUNG SILANG (Dibuat Dengan Metode Penggilingan Basah). Skripsi thesis, Universitas Airlangga.

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Abstract

Nanocrystals is homogenous drug crystals in nanometer domain stabilized with stabilizer such as carboxymethyl chitosan (CMCS). Crosslinking of CMCS with calcium chloride (CaCl2) enables to prolong drug absorption. It is expected that crosslinking nanocrystals with crosslinker will result in crosslinked nanocrystals with homogenous size and higher entrapment efficiency. This study is aimed to evaluate the influence of CaCl2 concentration on physical characteristics of crosslinked nanocrystals using andrographolide as model compound. 50 mg Andrographolide (Health Ingredients Co.,Ltd,China) was dispersed in 1%(w/v) CMCS (China Eastar Group Co.,Ltd.) then milled with 50 mm milling beads (Hosokawa, Japan) for 24 hours. Nanocrystals formed (F1) was then added with CaCl2 (F2:0,125%(w/v); F3:0,250%(w/v); F4:0,375%(w/v)) and stirred for 1 hour for crosslinking reaction. Nanocrystals formed were analyzed for its particle size, shape, and chemical bond changes. Crosslinked nanocrystals obtained have rough surfaces and irregular shape. X-Ray diffractogram of crosslinked and non-crosslinked nanocrystals shows crystalline peak of andrographolide disappear that means andrographolide dispersed in the system. The particle size of crosslinked nanocrystals (F2: 505,6 ± 7,7 nm; F3: 485,5 ± 9,5 nm; F4: 489,2 ± 10,3 nm) have smaller size than non-crosslinked nanocrystals (F1:512,8 ± 5,3 nm). There is no different between drug recovery of crosslinked and non-crosslinked nanosuspensions. Crosslinking of nanocrystals andrographolide-CMCS with CaCl2 was detected in all concentrations of CaCl2 added and also resulted in smaller particle size. Furthermore, the effectivity of crosslinked nanocrystals for prolonging drug absorption is needed through release study. Keywords: Nanocrystal, wet ball milling, andrographolide, carboxymethyl chitosan, CaCl2

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 33-16 Aza p
Uncontrolled Keywords: Nanocrystal, wet ball milling, andrographolide, carboxymethyl chitosan, CaCl2
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
RENISA AZALIA, 051211132094UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorRetno Sari, Dr., M.Sc., Apt.UNSPECIFIED
ContributorMaria Lucia Ardhani Dwi Lestari, Dr. rer. nat. , Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 May 2017 18:04
Last Modified: 11 May 2017 18:04
URI: http://repository.unair.ac.id/id/eprint/57352
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