KARAKTERISASI MIKROSFER NISIN DENGAN MATRIKS ALGINAT – GELATIN (2,25% : 0,25%) (Dibuat Menggunakan Metode Gelasi Ionotropik dengan Teknik Aerosolisasi)

I NYOMAN SURYADINATA ASTINA PUTRA, 051211131039 (2016) KARAKTERISASI MIKROSFER NISIN DENGAN MATRIKS ALGINAT – GELATIN (2,25% : 0,25%) (Dibuat Menggunakan Metode Gelasi Ionotropik dengan Teknik Aerosolisasi). Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this research is to characterize nisin microsphere prepared using ionotropic gelatin aerosolization technique with sodium alginate and gelatin (2.25 % : 0.25 %) as matrix polymer and calcium chloride (1.5 M) as the cross linker. The interaction between polymer and nisin was confirmed by the changes in the intensity and wave number on the FTIR spectra of nisin microsphere. X-Ray Diffraction of nisin microsphere showed amorf characteristic with no observable sharp peak of nisin in the diffractogram. Nisin microsphere has yield value 46.97 + 4.19 % and has moisture content 10.72 + 0.48 %. Nisin microsphere is spherical with smooth surface structure as displayed by scanning electron microscope (SEM). Nisin microsphere has size in the range 2.861 - 7.439 μm with mean particle diameter 4.048 + 0.069 μm. Mean particle diameter and particle size distribution were determined by optical microscope. Swelling characteristic was determined using gravimetric swelling index procedure and the maximum swelling index is 315.33 + 30.08 % achieved within 1 hr. In comparison with nisin microsphere prepared using only sodium alginate (2.5 %) there is significance different (P <0.05) in mean particle diameter. Keywords: Nisin, Microsphere, Ionotropic Gelation, Sodium Alginate, Gelatin, Characterization.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 34-16 Put k
Uncontrolled Keywords: Nisin, Microsphere, Ionotropic Gelation, Sodium Alginate, Gelatin, Characterization.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
I NYOMAN SURYADINATA ASTINA PUTRA, 051211131039UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutiek Purwanti, Dra., M.Si., Apt.UNSPECIFIED
ContributorDewi Melani Hariyadi, S.Si., M.Phil., Ph.D., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 May 2017 18:11
Last Modified: 11 May 2017 18:11
URI: http://repository.unair.ac.id/id/eprint/57354
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