PROFIL pH-LAJU REAKSI SALISILAMID PADA pH ASAM

ADISSA PARAMITHA, 051211131014 (2016) PROFIL pH-LAJU REAKSI SALISILAMID PADA pH ASAM. Skripsi thesis, Universitas Airlangga.

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Abstract

Salicylamide is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Salicylamide has the characteristics as a weak acid with pKa 8,1. As a weak acid, the increasing pH also increasing the ionization characteristic. The greater amount of the ionized phase makes it more chemically reactive. Salicylamide in buffer solution concentration 0,02 M and ionic strength 0,2 was made in various pH (2,0; 3,0; 4,0; 5,0; 6,0 ± 0,05) then incubated in temperature 40 ± 0,5 oC within six hours. Salicylamide solution sampled in 5 different times (0, 1h, 2h, 4h, and 6h) then analyzed using thin layer chromatography (TLC) method to determine its concentration. The TLC method using dichloromethane:acetone (4:1) as the mobile phase, TLC silica gel 60 F254 plate as the stationary phase, and Shimadzu CS-930 densitometer. The reaction rate (k) of salicylamide in various pH determined with 3 replications. The result showed that salicylamide follows first orde reaction. The value of k in pH 2,0; 3,0; 4,0; 5,0; 6,0 respectively 4,57x10-2 ± 3,52 x10-2; 2,61x10-2 ± 1,73x10-2; 3,78x10-2 ± 3,14x10-2; 3,47x10-2 ± 3,38x10-2; 1,50x10-2 ± 3,36x10-3 jam-1. There was no significant difference of k value between pH groups statistically. From a plot of pH versus log k, salicylamide pH-rate profile is obtained. Keywords: Salicylamide, pH-rate profile, Thin Layer Chromatography, stability, pH effect

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 35-16 Par p
Uncontrolled Keywords: Salicylamide, pH-rate profile, Thin Layer Chromatography, stability, pH effect
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
ADISSA PARAMITHA, 051211131014UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDewi Isadiartuti, Dr., M.Si., Apt.UNSPECIFIED
ContributorFebri Annuryanti, S.Farm., M.Sc., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 May 2017 18:17
Last Modified: 05 Jul 2017 21:05
URI: http://repository.unair.ac.id/id/eprint/57355
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