UJI AKTIVITAS MIKROBIOLOGI SIPROFLOKSASIN DALAM IMPLAN TULANG TERHADAP Staphylococcus aureus ATCC 25923 (KOMPOSIT IMPLAN : KITOSAN – BOVINE HYDROXYAPATITE DENGAN CROSS-LINKER GLUTARALDEHID)

WIDIASIH HAPSARI, 051211131037 (2016) UJI AKTIVITAS MIKROBIOLOGI SIPROFLOKSASIN DALAM IMPLAN TULANG TERHADAP Staphylococcus aureus ATCC 25923 (KOMPOSIT IMPLAN : KITOSAN – BOVINE HYDROXYAPATITE DENGAN CROSS-LINKER GLUTARALDEHID). Skripsi thesis, Universitas Airlangga.

[img]
Preview
Text (abstrak)
FF. F. 25-16 Hap u abstrak.pdf

Download (98kB) | Preview
[img] Text (fulltext)
FF. F. 25-16 Hap u.pdf
Restricted to Registered users only

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Staphylococcus aureus are a main causes of bone infection. 58% of bone infection in the world is caused by Staphylococcus aureus. Ciprofloxacin is as broad spectrum antibiotic used for bone infection and has good bone tissue penetration. To increase therapeutic effect of ciprofloxacin, local drug delivery system (implant) was suggested. The combination of ciprofloxacin - Bovine Hydroxyapatite (BHA) - chitosan (10 : 30 : 60) with cross-linker glutaraldehid 0.3% (formula 1) and 0.5% (formula 2) from the previous research give a controlled release of ciprofloxacin from implant on it therapeutic window (2-50 μg/mL). The aim of this study to determine the influence of glutaraldehid concentration towards the activity of ciprofloxacin in implant to Staphylococcus aureus ATCC 25923. In this study, antibiotic microbial assay was done using diffusion method. Sample test was ciprofloxacin solutions that was aquired from drug release test in 29 days. Diameter of inhibition zone to be potency (%). Potency analyzed using t – test on α = 0.05. The result showed that there was no significant difference of ciprofloxacin activity from both formula by the potency value 109.34% (formula 1) and 108.89% (formula 2). Potency ciprofloxacin in these two formulas is meet the requirement antibiotic potency in Farmakope Indonesia IV (80-125%). Keyword : ciprofloxacin – bone implant, chitosan - bovine hydroxyapatite (BHA), glutaraldehid, microbial assay, Staphylococcus aureus.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 25-16 Hap u
Uncontrolled Keywords: ciprofloxacin – bone implant, chitosan - bovine hydroxyapatite (BHA), glutaraldehid, microbial assay, Staphylococcus aureus.
Subjects: Q Science > QR Microbiology > QR1-502 Microbiology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
WIDIASIH HAPSARI, 051211131037UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorEsti Hendradi, Dra., M.Si, Ph.D., AptUNSPECIFIED
ContributorFaris Adrianto,, S.Farm., M.Farm., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 May 2017 23:33
Last Modified: 11 May 2017 23:33
URI: http://repository.unair.ac.id/id/eprint/57373
Sosial Share:

Actions (login required)

View Item View Item