KARAKTERISASI MIKROSFER NISIN DENGAN MATRIKS ALGINAT-GELATIN (2 : 0,5)% (Dibuat dengan menggunakan metode gelasi ionik teknik aerosolisasi)

INTAN AYU KARTIKA SARI, 05121132036 (2016) KARAKTERISASI MIKROSFER NISIN DENGAN MATRIKS ALGINAT-GELATIN (2 : 0,5)% (Dibuat dengan menggunakan metode gelasi ionik teknik aerosolisasi). Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this research was to determine physical characteristics of nisin microspheres with alginate-gelatin matrix (2 : 0.5)%. Nisin microsphere were prepared by ionotropic gelation method using aerosolization technique. Alginate-gelatin matrix (2 : 0.5)% and (2.5 : 0)% were used in this study. Resulting microspheres were characterised in terms of physical characteristics (morphology, particle size and swelling index). FTIR and X-ray diffraction studies were performed to investigate polymerpolymer or polymer-nisin interaction. Result showed that microspheres have spherical shape. Particle size of all formula were varied in the range 3.75-5.01 μm. In the presence of gelatin, maximum swelling index increased from 382.33% to 422.67%. An independent T-test of experiment was undertaken as statistical analysis. From the statistical test showed that presence of gelatin was significantly different in particle size and swelling index (sig < 0.05). Keywords: microsphere, ionotropic gelation, natrium alginate, gelatin, nisin, swelling index

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 26-16 Sar k
Uncontrolled Keywords: microsphere, ionotropic gelation, natrium alginate, gelatin, nisin, swelling index
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Creators:
CreatorsNIM/NIDN
INTAN AYU KARTIKA SARI, 05121132036UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutiek Purwanti, Dra., Apt., M.Si.UNSPECIFIED
ContributorEsti Hendradi, Dra., Apt., M.Si., Ph.DUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 May 2017 23:38
Last Modified: 11 May 2017 23:38
URI: http://repository.unair.ac.id/id/eprint/57374
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