OPTIMASI FORMULA TABLET LEVOFLOKSASIN DENGAN PENGIKAT PVP K-30 DAN DISINTEGRAN SODIUM STARCH GLYCOLATE

MAHRUS NAUFAL NURUDDIN, 051211132017 (2016) OPTIMASI FORMULA TABLET LEVOFLOKSASIN DENGAN PENGIKAT PVP K-30 DAN DISINTEGRAN SODIUM STARCH GLYCOLATE. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this study was to determine the effects of PVP K-30 and Sodium Starch Glycolate againts tablet physical quality profile and dissolution of the tablet as well as the optimum formula of the Levofloxacin tablet. The formula made by Factorial Design 22 which has two factors and two levels on each factor. Four formulas were made by wet granulation method using 2% and 4% of PVP K-30 and 2% and 4% of Sodium Satrch Glycolate. Before compressing, the particle size distribution, amount of fines, moisture content, flow properties and angle of repose of the granules were evaluated. Once compressed, the physical quality evaluation (hardness, friability and disintegration) also dissolution test were performed on the tablets. The data obtained were statistically analyzed using the Minitab 17 software. The result showed that PVP K-30 increase the tablet hardness, the friability and the disintegration time but lower the dissolution, while Sodium Starch Glycolate decrease the hardness, increase the friability, insignificantly decrease the disintegration time and extend the dissolution. Area on the Overlaid Contour plot showed the optimum formula with feasible tablet physical quality profile (friabilty, disintegration time) and dissolution rate. Further research are needed. Keyword: Levofloxacin; PVP K-30; Sodium Starch Glycolate; Factorial design; Tablet physical quality profile; Dissolution rate.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 49-16 Nur o
Uncontrolled Keywords: Levofloxacin; PVP K-30; Sodium Starch Glycolate; Factorial design; Tablet physical quality profile; Dissolution rate.
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
MAHRUS NAUFAL NURUDDIN, 051211132017UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDwi Setyawan, Dr., S.Si., M.Si., Apt.UNSPECIFIED
ContributorBambang Widjaja, Drs., Apt., M.SiUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 16 May 2017 17:51
Last Modified: 16 May 2017 17:51
URI: http://repository.unair.ac.id/id/eprint/57442
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