PENGARUH pH BASA TERHADAP STABILITAS SALISILAMIDA

WISNU PRASETYO UTOMO, 051211132042 (2016) PENGARUH pH BASA TERHADAP STABILITAS SALISILAMIDA. Skripsi thesis, Universitas Airlangga.

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Abstract

Salicylamide is a derivative of salicylic acid with analgesic effect. Salicylamide is a weak acid with value of pKa 8,2. It causes salicylamide become unstable at a range of 2 units above the pKa. The stability of salicylamide in various pH (7,0; 8,0; 9,0; 10,0; and 11,0) has been studied. The buffer solution 3000 mg/L of salicylamide in various pH were studied at 40 ± 0,5oC for 6 hours. Then it was determined at different times (0h, 1h, 2h, 4h, and 6h) and analysed using Thin Layer Chromatography (TLC) – Densitometry. The analysis is done using silica gel TLC plates 60 F254 as the stationary phase and a mixture of dichloromethane : acetone (4 : 1 v/v) as the mobile phase. The results showed that salicylamide follows first order reaction. Salicylamide at various pH buffer solution (7,0; 8,0; 9,0; 10,0; and 11,0) have rate constant (k) value 2,30.10-2 ± 1,22.10-2 ; 3,73.10-2 ± 1,89.10-2 ; 2,06.10-2 ± 0,54.10-2; 3,64.10-2 ± 0,39.10-2; and 1,40.10-2 ± 0,28.10-2 hour-1, respectively. Rate constant at pH 11 is the lowest than others due to resonance effect and resistance to nucleophilic attack by hydroxide ion. Keywords : salicylamide, stability, tlc – densitometry, pH

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. F. 58-16 Uto p
Uncontrolled Keywords: salicylamide, stability, tlc – densitometry, pH
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
WISNU PRASETYO UTOMO, 051211132042UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDewi Isadiartut, Dr., M.Si., Apt,UNSPECIFIED
ContributorFebri Annuryanti, M.Sc., Apt,UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 16 May 2017 19:50
Last Modified: 16 May 2017 19:50
URI: http://repository.unair.ac.id/id/eprint/57452
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