Setijo Rahaju, Anny and Meidi, Aniek and Mastutik, Gondo and Mustokowati, Sjahjenny and Mustika, Arifa (2016) Correlation between blood serum PSA level and MMP-2 in prostate adenocarcinoma. Indonesian Journal of Urology (66). pp. 79-84. ISSN 2355-1402

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Abstract

This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproainose-2 (MMP-2) expressan in patient with prostate adenocarcinoma. Material and method: Prostate cancer patients data from January 2009 to May 2012 were collected included patient the Department of Pathology,Soetomo General Hospital Surabaya. Data collected included potient medical document, PSA blood examination and histopathological examination. Histopothology slides ond paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients were re-read, then the samples that met the inclusion criteia were stained by imnunohistochemistry using antibodies MMP-2 I,Result: Data collection was done to obtain data samples of prostate cancer patient in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70 - 79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were beetween 8.6-594.41 ng/ml. Spearman's test, performed in this study showed a positive correlation (onetailed) (correlation coefficient (r)0431 , p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinomo. Conclusion: Blood PSA level correlation positively with MMP-2 expression in prostate adenocarcinoma.

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