Peningkatan Kolesterol pada Tikus Putih (Rattus Novergicus) Akibat Diet Tinggi Lemak Jenuh

Argarini, Raden and Sri Rejeki, Purwo and Purwanto, Bambang and Soetjipto, Harlina (2010) Peningkatan Kolesterol pada Tikus Putih (Rattus Novergicus) Akibat Diet Tinggi Lemak Jenuh. Majalah Ilmu Faal Indonesia, 9 (3). pp. 156-161. ISSN 0215-1995

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Abstract

Diet tinggi lemak rantai jenuh ikut berperan sebagai penyebab meningkatnya prevalensi obesitas dan sindroma metabolik A high saturated fatty chains diet play a role in the increasing prevalence of obesity and metabolic syndrome. Profil lipid darah merupakan indikator yang penting untuk mengetahui faktor resiko kelainan kardiovaskuler. Penelitian ini bertujuan untuk mengetahui pengaruh diet tinggi lemak jenuh terhadap pola peningkatan kolesterol darah Blood lipid profile is an important indicator to determine the risk factors of cardiovascular disorders. This study aims to determine the effect of a high saturated fats diet increase blood cholesterol patterns. Pemberian diet tinggi lemak dilakukan secara ad libitum selama sepuluh minggu kemudian dilakukan pengukuran berat badan, dan pemeriksaan kadar Kolesterol Total secara serial setiap minggu. Providing high-fat diet ad libitum conducted for ten weeks and then measured body weight and examination of Total Cholesterol levels in serial each week. Penelitian ini merupakan penelitian eksperimental murni dengan the randomized separated pretest postest control group design. Rattus norvegiscus galur Wistar sebanyak 44 ekor dibagi secara random menjadi dua kelompok yaitu kelompok kontrol dengan diet standar dan kelompok perlakuan dengan diet tinggi lemak selama sepuluh minggu. This research is true experimental with the randomized experimental pretest posttest control group separated design. 44 male Rattus norvegiscus strain Wistar were divided randomly into two groups: control group with standard diet and treatment groups with a high-satureted fat diet for ten weeks. Tiap minggu dilakukan pengukuran berat badan dan pemeriksaan kadar kolesterol darah. Each week body weight and blood cholesterol was measured. Analisis data menggunakan independent sample t test dan analisis korelasi Pearson. Analysis of data using independent sample t test. Hasil pengukuran praperlakuan didapatkan rerata berat badan kelompok kontrol 159.5 ± 25,6 gram dan kelompok perlakuan 161.5 ± 27.7 gram. The measurement results before treatment found that mean body weight in control and treatment group was 159.5 ± 25.6 g and 161.5 ± 27.7. Kadar Kolesterol kontrol 87.25 ± 5.74 mg/dl dan kelompok perlakuan 83.5 ± 6.61 mg/dl. Cholesterol in control and treatment group was 87.25 ± 5.74 mg / dl and 83.5 ± 6.61 mg / dl. Peningkatan kadar kolesterol darah mulai terjadi pada minggu ke-2 pemberian diet tinggi lemak walaupun tidak menunjukkan perbedaan yang bermakna. Increased blood cholesterol levels began to occur at week 2 of high-fat diet, although did not show significant difference. Sebagai kesimpulan, diet tinggi lemak selama 10 minggu menyebabkan terjadinya peningkatan kadar kolesterol plasma namun tidak cukup untuk menyebabkan perbedaaan yang bermakna. In conclusion, high-fat diet for 10 weeks resulted in increased plasma cholesterol levels but not enough to cause a significant difference.

Item Type: Article
Uncontrolled Keywords: High Saturated fat diet, cholesterol, body weight, obesity
Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: 01. Fakultas Kedokteran > Ilmu Faal
Creators:
CreatorsNIM/NIDN
Argarini, RadenUNSPECIFIED
Sri Rejeki, PurwoUNSPECIFIED
Purwanto, BambangUNSPECIFIED
Soetjipto, HarlinaUNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 06 Aug 2017 23:23
Last Modified: 06 Aug 2017 23:38
URI: http://repository.unair.ac.id/id/eprint/59896
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