UJI TOKSISITAS PRA KLINIS FORMULA VAKSIN ROTAVIRUS TERHADAP GAMBARAN HISTOPATOLOGI ORGAN USUS HALUS KELINCI JANTAN

DIANA NURJANAH, 061311133017 (2017) UJI TOKSISITAS PRA KLINIS FORMULA VAKSIN ROTAVIRUS TERHADAP GAMBARAN HISTOPATOLOGI ORGAN USUS HALUS KELINCI JANTAN. Skripsi thesis, Universitas Airlangga.

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Abstract

This research aimed to prove the influence of administered orally rotavirus vaccine formula from P.T Biofarma on histopathological changes of small intestine in male rabbits (Oryctolagus cuniculus). Six male rabbits were divided randomly into two groups and administered orally based on the treatment. The treatment consists of administered sucrose 1 ml orally (P0) and the administered of rotavirus vaccine formula P.T Biofarma 1 ml orally (P1). Rabbits adapted in BSL-3 for 7 days with adlibitum food and water before treatment. 1 ml sucrose and 1 ml rotavirus vaccine formula from P.T Biofarma was administered orally on day-0, day-11 and day-22. Then, on day 56 all rabbits euthanized for small instestine sample collection. The histopathological feature of small intestine were examined by using Modified Ciarlet et al., (1998) scoring methode. This research was analyzed using Mann-Whitney Test, then Mann-Whitney Test of statistical analyses showed that rotavirus vaccine formula has no effect on histopathological features of male rabbit’s small intestine organ (p > 0.05).

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH. 43/17 Nur u
Uncontrolled Keywords: male rabbits (Oryctolagus cuniculus), rotavirus vaccine formula, BSL-3, Mann-Whitney U Test, small intestine
Subjects: Q Science > QR Microbiology > QR1-502 Microbiology
Q Science > QR Microbiology > QR355 Virology
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsEmail
DIANA NURJANAH, 061311133017UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorKuncoro Puguh Santoso, Dr., drh., M.Kes.UNSPECIFIED
ContributorEndang Suprihati, Dr., drh., MS.UNSPECIFIED
Depositing User: Mrs Nadia Tsaurah
Date Deposited: 08 Aug 2017 21:56
Last Modified: 08 Aug 2017 21:56
URI: http://repository.unair.ac.id/id/eprint/60099
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