Hadi Susanto, Agung and Johanes Nugroho (2013) Manajemen Pasien Risiko Tinggi Penyakit Jantung Koroner dengan Kadar Serum Low-Density Lipoprotein (LDL) yang Rendah. In: PKB XV Current Management in Cardiology Practice. Departemen-SMF Penyakit Kardiologi dan Kedokteran Vaskular FK Unair, pp. 129-147. ISBN 978-602-18458-1-3

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Abstract

Dyslipidemia is an important etiologic componet to cerebrovascular, peripheral vascular and coronary heart disease worlwide. Most studies have shown that the 10% of the population with the highest LDL (low density lipoprotein) levels account for only 20-30% of the CHD (coronary heart disease) events.Conversely 70-80% of CHD events occur in patients with so called "normal' or "near-normal" levels. Standar guidelines theraphy 6-7 years ago focus treatment only on those with very high cholesterol levels. New approaches in last few years include more intensive lowering of LDL-cholesterol levels, reducing triglycerides/non-HDL components and raising the high-density lipoproteins (HDL) cholesterol levels. High triglycerides or too low HDL-cholesterol, also contribute to CHD risk and these abnormatlities often cluster with other risk factors. Inpatients whose triglyceride levels remain high (>200 mg/dl) or HDL-cholesterol levels low (< 40 mg/dl) even after have achieved their LDL cholesterol goals, the NCEP ATP III gudelines recommed a multifactorial lifestyle approach to reducing risk for CHD even after LDL-cholesterol.

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