KINERJA VITAMIN E (α-Tocopherol) SEBAGAI ANTIOKSIDAN TERHADAP SEL SPERMATOGENIK DAN EKSPRESI SITOCHROM C SPERMATOZOA MENCIT YANG DIPAPAR 2,3,7,8- TETRACHLORODIBENZO-P-DIOXIN

AYU IRA MARITA, 061314153002 (2017) KINERJA VITAMIN E (α-Tocopherol) SEBAGAI ANTIOKSIDAN TERHADAP SEL SPERMATOGENIK DAN EKSPRESI SITOCHROM C SPERMATOZOA MENCIT YANG DIPAPAR 2,3,7,8- TETRACHLORODIBENZO-P-DIOXIN. Thesis thesis, Universitas Airlangga.

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Abstract

Reproductive disorders in animals can cause temporary or permanent infertility. Infertility can be caused due to various factors, such as exposure to toxic substances into the body continuously. One example of a very dangerous toxic substances in the body is 2,3,7,8-tetracholordenzo-p-dioxin (TCDD). TCDD is famous spermatogenic cells. Vitamin E 11, 20, 37 E 37mg / kg / day for 15 days can minimalizir effect of TCDD 100ng/kg/day. HE staining and testing the expression of cytochrome C is done to know how is TCDD effect. The study design using a completely randomized design. The calculation of the number of spermatogenic cells and expression of cytochrome C was calculated in each treatment by using analysis of variants (ANOVA) and significantly different when followed by Duncan test. The results of this study prove that the treatment group P1, P2, and P3 are given vitamin E showed increased spermatogenic cell number compared to the positive control (P0) and decreased expression of cytochrome C spermatozoa. The conclusion from this study is that TCDD greatly affect the process of spermatogenesis of male mice by inhibiting its development in phase spermatid and vitamin E can inhibit the performance of TCDD in the body of male mice by tying a series of TCDD carbon chain so that it becomes a substance that decreases its toxicity in animals.

Item Type: Thesis (Thesis)
Additional Information: KKC KK TBR 10/17 Mar k
Uncontrolled Keywords: TCDD, α-tocopherol, Mus musculus, spermatogenic cells, sitochrom C
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine
Divisions: 06. Fakultas Kedokteran Hewan > Reproduksi Veteriner
Creators:
CreatorsEmail
AYU IRA MARITA, 061314153002UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorWurlina, Prof.,Dr.,drh.,MSUNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 10 Sep 2017 23:54
Last Modified: 10 Sep 2017 23:54
URI: http://repository.unair.ac.id/id/eprint/61371
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