Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B (NF-kB) p65 and calcineurin expression play a role in the regulation of muscle regeneration process through aerobic exercise in HIV patients

Mardjiati Mei wulan, Sri and Laswati P, Hening and Purnomo, Windhu and Pangkahila, Alex and Nasronudin and Hadi, Usman (2017) Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B (NF-kB) p65 and calcineurin expression play a role in the regulation of muscle regeneration process through aerobic exercise in HIV patients. Bali Medical Journal, 6 (2). pp. 421-426. ISSN p2089-1180/e2302-2914

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Abstract

Background: Human Immunodeficiency Virus infection is a chronic disease with inflammatory conditions and experience progressive muscle wasting with increasing of tumor necrosis factor alpha. Physical exercise is a non-pharmacological therapy which stimulates the muscle regeneration. Moderate intensity of aerobic exercise is safe for human immunodeficiency virus patients. Whether tumor necrosis factor- alpha plays a role in the process of muscle regeneration in human immunodeficiency virus infection who have had tumor necrosis factor alpha level higher. Objective: To explain the role of tumor necrosis factor alpha, NF-kappaB, and Calcineurin expression in the regulation of muscle regeneration process. Methods: Research subjects are population with clinical stage II human immunodeficiency virus infection. Subjects were grouped into two: I (n = 9) as subjects who got aerobic exercise for 8 weeks and C (n = 9) as subjects who were observed for 8 weeks. Muscle samples were taken from the vastus lateralis muscle biopsies that were performed 24 hours after the last physical exercise. And the immunohistochemical examination was done with anti- tumor necrosis factor alpha monoclonal antibody, anti- NF-kappaB, and anti-calcineurin. Results: The relationship of muscle contraction to Tumor necrosis factor alpha and calcineurin expression, and to the other myogenic factors was significant, but not to NF-kappaB p65 expression. Conclusion: Muscle regeneration process needs TNF-alpha and NF-kB p65 expression as regulators with TNF-alpha, NF-kB p65, myogenic factors as the path of exercise and calcineurin expression as a regulator with calcineurin myogenic factors as the path of exercise.

Item Type: Article
Uncontrolled Keywords: Human Immunodeficiency Virus, aerobic exercise, muscle regeneration process, Tumor Necrosis Factor Alpha
Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: 01. Fakultas Kedokteran > Ilmu Fisik & Rehab
Creators:
CreatorsNIM/NIDN
Mardjiati Mei wulan, SriUNSPECIFIED
Laswati P, Heninglputra04@yahoo.com
Purnomo, WindhuUNSPECIFIED
Pangkahila, AlexUNSPECIFIED
NasronudinUNSPECIFIED
Hadi, UsmanUNSPECIFIED
Depositing User: Bayu Yulianti
Date Deposited: 12 Sep 2017 00:01
Last Modified: 12 Sep 2017 00:08
URI: http://repository.unair.ac.id/id/eprint/61388
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