Interleukin-1b expression on periodontitis patients in Surabaya

Prahasanti, Chiquita (2010) Interleukin-1b expression on periodontitis patients in Surabaya. Dental Journal, 43 (4). pp. 201-214. ISSN 1978-3728

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Background: Periodontal disease, commonly known as periodontitis is an infectious disease which has multifactorial etiologic factors. It may affect everybody in any ages with no gender nor sex predilection and usually can be detected under routine clinical examination. This disease is a manifestation of local factors, host factor and environmental factors, resulting in periodontal tissue damage which may cause tooth mobility and tooth loss. Interleukin-1 is a pro-inflammatory protein which functions primarily as inflammatory mediator in host innate immune responses. IL-1 is a regulator, affecting many biological activities including proliferation, development, homeostasis, regeneration, repair and inflammation which contribute to tissue damage and alveolar bone resorption. Purpose: This research was aimed to reveal the basic pathogenesis of periodontitis and could determine the future definitive treatment for patients with periodontitis. Methods: Data were obtained from 40 patients with aggressive periodontitis and 40 patients with chronic periodontitis. Samples were collected from periodontal tissue patients and protein expression of IL-1b was performed with immunohistochemistry. Results: Most female patient suffer aggressive periodontitis and chronic periodontitis. The datas were analyzed with t-test. The t values result was -8623, significance 0.001, with a = 5%, which indicated there was significant difference in IL-1b expression between aggressive and chronic periodontitis. The box plot diagram showed marked difference in distribution of protein expression of IL-1b between patients with aggressive periodontitis and chronic periodontitis. With a regression equation, it might be concluded that the protein expression of IL-1b might affect the incidence of aggressive periodontitis and chronic periodontitis. The OR value was calculated for 0.746 (sign.= 0.001), which indicate each increment of one unit protein expression of IL-1b will lead the risk for Aggressive periodontitis 0.746 times higher or if the protein expression of respondents increased one unit, the risk of chronic IL-1b periodontitis may be 1.34 times higher. Conclusion: This study elucidated that the elevation proteins expression of IL-1b in patients with chronic periodontitis demonstrated this cytokine as an indicator of inflammation. Key words: Aggressive periodontitis, chronic periodontitis, interleukin-1b abstrak

Item Type: Article
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Periodontics
Prahasanti, ChiquitaUNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 26 Sep 2017 19:39
Last Modified: 26 Sep 2017 19:39
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