Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata.

Mulyadi Tanjung, Drs., M.S. and Tjitjik Srie Tjahjandarie, Ph.D and Mulya Hadi Santoso, Dr. Apt. (2013) Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata. Asian Pacific Journal of Tropical Disease, 3 (5). pp. 401-404. ISSN 2222-1808

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Objective To determine antioxidant and cytotoxic activity of two flavanones, pinocembrin (1) and pinostrobin (2) from the rhizomes of Kaempferia pandurata. The chemical structures of both compounds were determined based on spectroscopic data, including UV, IR, MS and NMR spectra. Methods The antioxidant activities of pinocembrin (1) and pinostrobin (2) were assayed by using 2,2-diphenyl-1-picrylhydrazyl. Cytotoxic assay was done by using brine shrimp lethality test, and cytotoxic properties was tested against murine leukemia P-388 cells. Results Compounds 1-2 were evaluated for their antioxidant properties against DPPH, showing their IC50 were 5 816 and 6 268 μmol/L; brine shrimp lethality test: LC50 23.3 and 60.5 μg/mL; murine leukemia P-388: IC50 176.3 and 218.5 μmol/L. Conclutions The results indicated that pinocembrin (1) was slightly more active than pinostrobin (2).

Item Type: Article
Uncontrolled Keywords: Flavanone; Pinocembrin; Pinostrobin; Kaempferia pandurata; Antioxidant; Cytotoxic;
Subjects: Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Mulyadi Tanjung, Drs., M.S.UNSPECIFIED
Tjitjik Srie Tjahjandarie, Ph.DUNSPECIFIED
Mulya Hadi Santoso, Dr. Apt.UNSPECIFIED
Depositing User: Mr Akhmad Nurfizal Reza
Date Deposited: 26 Sep 2017 16:40
Last Modified: 26 Sep 2017 16:40
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