PROTECTIVE EFFECT OF PROPOLIS EXTRACT IN KIDNEY MALE MICE (Mus musculus) INDUCED BY LEAD ACETATE

CITRASARI HENRA PUTRI, 061311133266 (2017) PROTECTIVE EFFECT OF PROPOLIS EXTRACT IN KIDNEY MALE MICE (Mus musculus) INDUCED BY LEAD ACETATE. Skripsi thesis, Universitas Airlangga.

[img]
Preview
Text (ABSTRAK)
KH.387.17 . Put.p - ABSTRAK.pdf

Download (19kB) | Preview
[img] Text (FULLTEXT)
KH.387.17 . Put.p - SEC.pdf
Restricted to Registered users only until 4 October 2020.

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

The aim of this research was to investigate the protective effect of propolis extract from Apis mellifera, on histopathological changes of the kidney induced by lead acetate in mice (Mus musculus). 25 male mice were randomly divided into five groups and administered orally with different treatments for 45 days. The first seven days were the adaptation period. The next three days continued with premilinary treatment. The last 35 days the treatment were Group C- (CMC-Na 1.5% and Tween 80 0.5% continued with aquadest one hour after the first administration), Group C+ (CMC-Na 1.5% and Tween 80 0.5% and continued with 20 mg/kg bw of lead acetate), and treatment group T1, T2, T3 (200, 400, 800 mg/kg bw propolis extract and continued with 20 mg/kg bw of lead acetate). After treatments, tissues were processed, and histopathological evaluation were examined using Modified Arshad Scoring method. The result of groups which received propolis extract and lead acetate showed significant difference comparing to positive control treatment group. The mean value of necrosis and tubular cast in group T3 is the lowest, while the mean value of hydropic degeneration is the highest. It indicates the reversible cell injury. Thus, the effective dose of propolis extract used in this research is 800 mg/kg bw.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH.Put p
Uncontrolled Keywords: propolis, lead, reactive oxygen species, free radicals, kidney
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > Including veterinary genetics, ethology, anatomy, physiology, embryology, pathology
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsEmail
CITRASARI HENRA PUTRI, 061311133266UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorUNSPECIFIEDUNSPECIFIED
ContributorUNSPECIFIEDUNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 27 Dec 2017 16:06
Last Modified: 27 Dec 2017 16:06
URI: http://repository.unair.ac.id/id/eprint/62382
Sosial Share:

Actions (login required)

View Item View Item