Airlanggon A, a new isoprenylated benzoic acid fromthe roots of Erythrinasu bumbrans and their antioxidant and antimalarial activities

Tjahjandarie, Tjitjik Srie and Saputri, Ratih Dewi and Firmansyah, Mohammad Yusuf and Tanjung, Mulyadi (2015) Airlanggon A, a new isoprenylated benzoic acid fromthe roots of Erythrinasu bumbrans and their antioxidant and antimalarial activities. Der Pharma Chemica, 7 (3). pp. 119-124. ISSN 0975-413X

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Abstract

This research was aimed to determine the antioxidant and antimalarial activities from a new isoprenylated benzoic acid, airlanggon A (1) isolated from the roots of Erythrina subumbranstogether with known compounds, methyl 4,6- dihydroxy-2,5-dimethyl benzoic acid (2) and 8-hydroxy-7,4’-dimethoxy isoflavone (3) from the stem barkof E. subumbrans. The structure of three compounds were elucidated by UV, IR, 1D and 2D NMR, and HR-ESI-MS spectra. Compounds 1-3 were evaluated for their antimalarial and antioxidant properties against P. falciparum and DPPH radical scavenging activities.Compounds 1–3 showing their antimalarial activity against P. falciparum with IC50 of 1.98; 1.67 and 1.64 μg/mL and antioxidant properties against DPPH, showing their IC50of 266.48 ; 34.61 and 22.33 μg/mL respectively.The results indicate that 8-hydroxy-7,4’-dimethoxy isoflavone (3) slightly more active thanmethyl 4,6-dihydroxy-2,5-dimethyl benzoic acid (2)and airlanggon A (1) showed moderate activities.

Item Type: Article
Uncontrolled Keywords: Airlanggon A, Methyl isoprenyl benzoic acid, Erythrina subumbrans, Antioxidant, Antimalarial
Subjects: Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsEmail
Tjahjandarie, Tjitjik SrieUNSPECIFIED
Saputri, Ratih DewiUNSPECIFIED
Firmansyah, Mohammad YusufUNSPECIFIED
Tanjung, MulyadiUNSPECIFIED
Depositing User: Mr Akhmad Nurfizal Reza
Date Deposited: 12 Oct 2017 23:32
Last Modified: 12 Oct 2017 23:32
URI: http://repository.unair.ac.id/id/eprint/63042
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