EFEK PEMBERIAN PARICALCITOL TERHADAP KADAR SERUM KALSIUM, FOSFAT, HORMON PARATIROID INTACT DAN TATRATE-RESISTANT-ACIDPHOSPHATASE TYPE 5B PADA PASIEN PENYAKIT GINJAL KRONIK STADIUM 5 DENGAN HEMODIALISA

Muh. Isnaini Zuhri, S.Farm., Apt, 051415153002 (2017) EFEK PEMBERIAN PARICALCITOL TERHADAP KADAR SERUM KALSIUM, FOSFAT, HORMON PARATIROID INTACT DAN TATRATE-RESISTANT-ACIDPHOSPHATASE TYPE 5B PADA PASIEN PENYAKIT GINJAL KRONIK STADIUM 5 DENGAN HEMODIALISA. Thesis thesis, Universitas Airlangga.

[img]
Preview
Text (abstrak)
abstrak.pdf

Download (100kB) | Preview
[img] Text (full text)
Muh Isnaini Zuhri 051415153002.pdf
Restricted to Registered users only until 16 October 2020.

Download (1MB)

Abstract

Background: Mineral and bone disorder is a common complication in hemodialysis (HD) patients and leads to substantial increases in fracture rate, morbidity, and mortality. It is associated with secondary hyperparathyroidism. Paricalcitol has been shown to reduce secondary hyperparathyroidsm and its complication with minimal calcemic and phosphatemic activity. Tartrate-resistant acid phsophatase (TRAP) 5b is a new marker of bone resorption that is unaffected by renal dysfunction. However, information about its efficacy on bone resorption is lacking. This study was designed to determine the effect of paricalcitol therapy on calcium, phosphate, intact parathyroid hormone and TRAP-5b in end stage renal disease. Methods : A Prospective cohort study was carried out from September to November in Undaan Wetan Hospital, Surabaya. There were 9 patients of end stage renal disease with mineral and bone disorders, 4 on paricalcitol therapy, received 5 μg of paricalcitol every HD session for three months. Five patients in group without paricalcitol. Levels of calcium, phosphate, iPTH, and TRAP-5b were measured before initiation of study and after three months therapy for both groups. Results: The baseline characteristics between two groups were similiar. Administration of paricalcitol caused no significant change in all parameters. However, in group without paricalcitol group, there was a significant increase level of iPTH (p=0.005) and TRAP-5b (p=0.022). The differences test (pooled t-test) between group showed there were no significant differences between two groups in all tested parameters. Furthermore, a correlation test between iPTH and marker TRAP-5b, showed significant positive correlation (p=0.002, r =0.476). Conclusion: In HD patients, administration of three months paricalcitol maintained levels of iPTH and TRAP-5b without affect calcium and phosphate levels compared without paricalcitol therapy. A higher level of iPTH may correlate with higher level of TRAP5b.

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TFK 16/17 Zuh e
Uncontrolled Keywords: Paricalcitol, hemodialyisis, calcium, phosphate, iPTH, TRAP-5b
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
Muh. Isnaini Zuhri, S.Farm., Apt, 051415153002UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBudi Suprapti, Dr. , M. Si., AptUNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 15 Oct 2017 20:47
Last Modified: 15 Oct 2017 20:47
URI: http://repository.unair.ac.id/id/eprint/63884
Sosial Share:

Actions (login required)

View Item View Item