IDENTIFIKASI METABOLIT SEKUNDER DARI FRAKSI 9 EKSTRAK ETIL ASETAT JAMUR ENDOFIT Kabatiella caulivora var. A YANG DIISOLASI DARI Alyxia reinwardtii Bl.

IZZATUL LAILI, 051211132001 (2017) IDENTIFIKASI METABOLIT SEKUNDER DARI FRAKSI 9 EKSTRAK ETIL ASETAT JAMUR ENDOFIT Kabatiella caulivora var. A YANG DIISOLASI DARI Alyxia reinwardtii Bl. Skripsi thesis, Universitas Airlangga.

[img]
Preview
Text (ABSTRAK)
FF.FT.07.17 . Lai.i - ABSTRAK.pdf

Download (58kB) | Preview
[img] Text (FULLTEXT)
FF.FT.07.17 . Lai.i - SEC.pdf
Restricted to Registered users only until 31 October 2020.

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Endophytic fungi is one of the main sources of new antibioticproducing microbes (Yu et al., 2010). Kabatiella caulivora var.A is one of the endophytic fungi that isolated from Alyxia reinwardtii (Sugijanto, 2009). Fraction 9 of its ethyl acetate extract was known have antimicobe activity (Prihaningrum, 2011) so interesting to identify the compound of secondary metabolite in the fractions 9. Purification fraction 9 using column chromatography with Sephadex LH-20 and methanol p.a resulted 6 subfractions. Subfraction 9.1 shown positive when sprayed by anisal-dehyde-H2SO4 p reagent. The results of analysis using GC-FID show two dominant peaks at 14,83 minutes and 20,38 minutes that separated well, so that the analysis continued by GCMS. The results of analysis using GC-MS showed two dominant peaks, each of them has retention time at 9.752 minutes and 15.047 minutes. Using Wiley 7n.1 database, compound of peak I identified as massoia lactone and compound of peak II is 3,5-dihydroxydecanoic acid deltalactone. Both of lactone was isolated from some plants and fungus, and was known have activity as antibacteria, anticandida, and potentially as immunomodulator. In conclusion, massoia lactone and 3,5- dihydroxydecanoic acid δ-lactone identified as secondary metabolites that support antimicrobial activity in fraction 9 of ethyl acetate extract of endophytic fungi Kabatiella caulivora var. A that isolated from Alyxia reinwardtii.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.FT.07/17 Lai i
Uncontrolled Keywords: Endophytic fungi, Kabatiella caulivora, Alyxia reinwardtii Bl., Massoia lactone, 3,5-dihydroxydecanoic acid delta-lactone
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
IZZATUL LAILI, 051211132001UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorGunawan Indrayanto, Prof., Dr.rer.nat , Apt.UNSPECIFIED
ContributorNoor Erma, Prof., Dr., N.S., M.S.,UNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 18:58
Last Modified: 17 Jan 2018 19:50
URI: http://repository.unair.ac.id/id/eprint/65093
Sosial Share:

Actions (login required)

View Item View Item