Efikasi Pemberian Topikal Campuran Produk Metabolit Amniotic Membrane Stem Cell (AMSC) dan Vitamin C setelah Microneedling pada Photoaging

ZADA FEBRIAL EFFENDY, 011218046306 (2017) Efikasi Pemberian Topikal Campuran Produk Metabolit Amniotic Membrane Stem Cell (AMSC) dan Vitamin C setelah Microneedling pada Photoaging. Thesis thesis, Universitas Airlangga.

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Abstract

Aging skin due to extrinsic factors there is a decrease in growth factors that will result in degradation of the structure of the skin, so the skin will look older than it should be. Nowadays more ways to prevent aging, including lifestyle management programs, nutrition, hormone use, the environment, and treatment with stem cells. Amniotic membranes are currently a good candidates as cellular therapy and regenerative medicine. In the amniotic membrane stem cell (AMSC) culture process, there are several bioactive materials in the culture medium called metabolite product. Vitamin C is a water-soluble vitamin whose function has been widely known in the field of dermatology as an agent of depigmentation, antioxidants, and collagen synthesis. Topical combination of metabolite product AMSC (MP-AMSC) and Vitamin C are expected to have an effect on clinical photoaging improvement Purpose: to evaluated the anti-aging effect of topical combination MP-AMSC and vitamin C after microneedling compare with MP-AMSC alone. Methods: a total 24 photoaging women were included in this experimental analitic, controlled, matching research. Each participant’s face were allocated to topical combination of MP-AMSC and vitamin C in intervention group and MP-AMSC alone in control group. To enhance epidermal penetration, dermapen was used. Three treatment sessions were repeated at two weeks interval. Results: Janus assessment of pore, wrinkle, spot (polarized), and spot (uv light) revealed statistically significant effect of topical combination MP-AMSC and vitamin C after microneedling (p<0,05). The only minimal adverse event was eritem. Conclusions: MP-AMSC and vitamin C improve the signs of skin aging and could be a potential option for skin rejuvenatio

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS.IKK 09/17 Eff e
Uncontrolled Keywords: metabolite product, amniotic membrane stem cell, vitamin C, microneedling, photoaging
Subjects: R Medicine > RL Dermatology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Kulit
Creators:
CreatorsEmail
ZADA FEBRIAL EFFENDY, 011218046306UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorCita Rosita S., Dr. dr. P, pKKCK), FINS-DV, FAA-DVUNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 30 Oct 2017 21:12
Last Modified: 30 Oct 2017 21:12
URI: http://repository.unair.ac.id/id/eprint/65173
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