UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SIRUP EKSTRAK ETANOL 70% JAHE MERAH (Zingiber officinale Rosc. var rubrum) SECARA IN VITRO

SHAHNAS SHIHHAH, 051311133022 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SIRUP EKSTRAK ETANOL 70% JAHE MERAH (Zingiber officinale Rosc. var rubrum) SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

Gastritis is a digestive disorder that occurs when the aggressive and defensive factors in the stomach is not balanced. One of the clinical manifestations of gastritis is excessive ordinary gases in the digestive tract or commonly called flatulent. This research aims to assess the antacid and antiflatulent activities of 70% ethanolic extract syrup of red ginger (Zingiber officinale Rosc. var rubrum). The extract was made into a syrup by using various concentrations of extract (1%, 2%, and 3%). Neutralizing effects and foam removal effect on artificial gastric acids was determined and compared with non-extract syrup as negative control. Based on the result of this study, it was found that all the test groups had an antiflatulent activity. The 1% test group could neutralize gastric acid with average duration of 34.38 ± 3.47 minutes and the residual foam level of 1.4 ± 0.1 cm. The 2% test group neutralized gastric acid with average duration of 106.23 ± 3.11 minutes and the residual foam level of 0.4 ± 0.1 cm. The 3% test group neutralized gastric acid with average duration of 11.39 ± 1.53 minutes and the residual foam level of 1.2 ± 0.2 cm. The ethanolic extract syrup preparation of red ginger (Zingiber officinale Rosc var rubrum) with 2% extract concentration had the highest activity both on antacid and anti-flatulent activities test when compared with the other two test groups. The 70% ethanolic extract syrup of red ginger (Zingiber officinale Rosc. var rubrum) was consistently possess antiflatulence activity in the artificial stomach model, while the antacid capacity test need to be performed to conclude whether this syrup have antacid activity or not.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.FT.43/17 Shi u
Uncontrolled Keywords: Zingiber officinale Rosc. var rubrum , anti-flatulent, antacid, in vitro
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
SHAHNAS SHIHHAH, 051311133022UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSukardiman, Prof., Dr., M.S., Apt.UNSPECIFIED
ContributorLusiana Arifianti, S.Farm.,M.FarmUNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:15
Last Modified: 17 Jan 2018 20:49
URI: http://repository.unair.ac.id/id/eprint/65212
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