AYU TARANTIKA INDRESWARI, 051311133041 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN DARI SEDIAAN SIRUP EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan Linn.) SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.
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Abstract
This study aimed to prove the neutral acid and anti-flatulent activities of Secang wood (Sappan Lignum) which has been formulated in antacid syrup used in vitro artificial gastric acid neutralization test based on Wu modification method, and anti-flatulence foam removal test based on Rezak in vitro method. The result of antacid activities group test of formula 1, formula 2 and formula 3 of secang wood ethanol extract syrup concentration 0,5% ; 1% and 2% showed positive acid neutralization activities with average duration of 35.15 ± 5.78 minutes for formula 1; 91,03 ± 6,76 minutes for formula 2 and 36,79 ± 1,93 minutes for formula 3. The activities result of anti-flatulence group test of formula 1, formula 2 and formula 3 of secang wood ethanol extract syrup concentration 0,5%; 1% and 2% showed foam removing activities with foam level rest 1.1 ± 0.05 cm for formula 1; 0.9 ± 0.12 cm for the formula 2 and 1.3 ± 0.06 cm for the formula 3. From One Way Anova and Post Hoc statistic analysis test continued by Least Significant Difference (LSD) test method. The p valued of the whole formulas for antacids and anti-flatulence activities was 0.000 (p <0.05), which showed a significant difference between the dosage of secang wood ethanol extract syrup compared to the negative control (syrup without extract). So the three dosages of formula 1, formula 2 and formula 3 can be stated had significant antacid and anti-flatulence activities. Thus can be concluded that secang wood ethanol extract syrup have antacid and anti-flatulence activities. And among the three formulas, formula 1 showed the most effective activity compared with others.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK2 FF.FT.46/17 Ind u | |||||||||
| Uncontrolled Keywords: | Caesalpinia sappan Linn., antacids, anti-flatulence | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Mr Binkol1 1 | |||||||||
| Date Deposited: | 28 Dec 2017 19:16 | |||||||||
| Last Modified: | 17 Jan 2018 20:52 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/65219 | |||||||||
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