UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN DARI SEDIAAN SIRUP EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan Linn.) SECARA IN VITRO

AYU TARANTIKA INDRESWARI, 051311133041 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN DARI SEDIAAN SIRUP EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan Linn.) SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aimed to prove the neutral acid and anti-flatulent activities of Secang wood (Sappan Lignum) which has been formulated in antacid syrup used in vitro artificial gastric acid neutralization test based on Wu modification method, and anti-flatulence foam removal test based on Rezak in vitro method. The result of antacid activities group test of formula 1, formula 2 and formula 3 of secang wood ethanol extract syrup concentration 0,5% ; 1% and 2% showed positive acid neutralization activities with average duration of 35.15 ± 5.78 minutes for formula 1; 91,03 ± 6,76 minutes for formula 2 and 36,79 ± 1,93 minutes for formula 3. The activities result of anti-flatulence group test of formula 1, formula 2 and formula 3 of secang wood ethanol extract syrup concentration 0,5%; 1% and 2% showed foam removing activities with foam level rest 1.1 ± 0.05 cm for formula 1; 0.9 ± 0.12 cm for the formula 2 and 1.3 ± 0.06 cm for the formula 3. From One Way Anova and Post Hoc statistic analysis test continued by Least Significant Difference (LSD) test method. The p valued of the whole formulas for antacids and anti-flatulence activities was 0.000 (p <0.05), which showed a significant difference between the dosage of secang wood ethanol extract syrup compared to the negative control (syrup without extract). So the three dosages of formula 1, formula 2 and formula 3 can be stated had significant antacid and anti-flatulence activities. Thus can be concluded that secang wood ethanol extract syrup have antacid and anti-flatulence activities. And among the three formulas, formula 1 showed the most effective activity compared with others.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.FT.46/17 Ind u
Uncontrolled Keywords: Caesalpinia sappan Linn., antacids, anti-flatulence
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
AYU TARANTIKA INDRESWARI, 051311133041UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSukardiman, Prof., Dr., M.S., Apt.UNSPECIFIED
ContributorLusiana Arifianti, S.Farm.,M.FarmUNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:16
Last Modified: 17 Jan 2018 20:52
URI: http://repository.unair.ac.id/id/eprint/65219
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