UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SEDIAAN SIRUP EKSTRAK ETANOL HERBA Mentha arvensis Linn. SECARA IN VITRO

RIRIN CHOIROTUN NISAK, 051311133033 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SEDIAAN SIRUP EKSTRAK ETANOL HERBA Mentha arvensis Linn. SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

The purpose of this study is to determine the antacid and antiflatulent activity of 96% ethanol extract syrup of Mentha arvensis Linn. herbs. This study was conducted in vitro by using artificial stomach models. Artificial gastric juice at pH 1.2 was pumped at 3 mL/min into the container of the artificial stomach (at 37℃), and it was pumped out at 3 mL/min at the same time and continuously stirred with a magnetic stirring apparatus. The antiflatulent activity in vitro using the same stomach and gastric acid model as in antacid activity test. The difference is, the antiflatulent activity test does not need artificial gastric acid infusion. In antacid activity test, a pH meter was connected to continuously monitor the changes of pH in the container of the artificial stomach. The duration of neutralization effect was determined when the pH value was returned to its initial value (pH 1.2). The antiflatulent activity test was considered complete after 20 min. The results showed that ethanol extract syrup of Mentha arvensis Linn. herbs has antacid and antiflatulent effects in vitro. Compared with the negative group, 96% ethanol extract syrup of “Herba Mint” was found to possess significant gastric acid neutralizing and defoaming effects. The duration for consistent neutralization sample was significantly longer than negative group and exhibited significant defoaming effects compared to negative group. The ethanol extract syrup of “Herba Mint” was consistently active in the artificial stomach model and is suggested to has antacid and antiflatunet effects similar to the active control drugs.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.FT.47/17 Nis u
Uncontrolled Keywords: Mentha arvensis Linn, antacid, antiflatulent, in vitro
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
RIRIN CHOIROTUN NISAK, 051311133033UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHerra Studiawan, Drs., MS.,UNSPECIFIED
ContributorLusiana Arifianti, S.Farm.,M.FarmUNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:16
Last Modified: 17 Jan 2018 20:54
URI: http://repository.unair.ac.id/id/eprint/65221
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