PENGARUH SUMBER KARBON ORGANIK TERHADAP PRODUKSI PROTEASE FIBRINOLITIK Bacillus sphaericus BM 9.1 DENGAN SOLID STATE FERMENTATION (SSF)

AFRILIA DIANA FITRI, 051311133075 (2017) PENGARUH SUMBER KARBON ORGANIK TERHADAP PRODUKSI PROTEASE FIBRINOLITIK Bacillus sphaericus BM 9.1 DENGAN SOLID STATE FERMENTATION (SSF). Skripsi thesis, Universitas Airlangga.

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Abstract

Fibrinolytic enzymes are a group of protease serine enzymes capable of destroying blood clots (fibrin) in various thrombotic diseases. Fibrinolytic enzyme sources can be obtained from microorganisms. Bacillus sp is one of the microorganisms that has the potential to produce fibrinolytic enzymes. Medium has an important role in growing and producing fibrinolytic enzymes. In a medium, sufficient carbon source is required for the growth of a bacterium. In microbial fermentation, carbon sources are indispensable for the formation of biomass and energy production. The medium used in this research is Nutrient agar medium with organic carbon source added. Sources of carbon used are glucose, fructose, sucrose, and starch with each 1% w/v concentration. Addition of carbon sources with 1% w/v concentration to the medium showed different effects on fibrinolytic enzymes production by Bacillus sphaericus BM 9.1. So among all the carbon sources tested, fructose yielded the highest fibrinolytic index (2.86 ± 0.03). The next step is to optimize the concentration of fructose carbon source. Optimization of fructose concentration to be tested at concentrations of 1%, 2%, 3%, and 4%. All concentrations has been tested, fructose 1% w/v concentration yielded the highest fibrinolytic index (2.82 ± 0.04).

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.KF.39/17 Fit p
Uncontrolled Keywords: Bacillus sphaericus, carbon source, fibrinolytic enzyme
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
AFRILIA DIANA FITRI, 051311133075UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorAchmad Toto Poernomo, Drs., M.Si., Apt.UNSPECIFIED
ContributorM. Faris Adrianto, S.Farm., M.Farm., Apt.UNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:37
Last Modified: 17 Jan 2018 21:14
URI: http://repository.unair.ac.id/id/eprint/65278
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