OPTIMASI DAN VALIDASI METODE KCKT UNTUK PENETAPAN KADAR PARASETAMOL, EFEDRIN HCl DAN GLISERIL GUAIAKOLAT DALAM SEDIAAN SIRUP OBAT BATUK-PILEK

ANISA RUMINTANG, 051311133105 (2017) OPTIMASI DAN VALIDASI METODE KCKT UNTUK PENETAPAN KADAR PARASETAMOL, EFEDRIN HCl DAN GLISERIL GUAIAKOLAT DALAM SEDIAAN SIRUP OBAT BATUK-PILEK. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of the present study was to obtain a valid HPLC method for determination of paracetamol, ephedrine HCl and glyceryl guaiacolate simultanously in cough-cold syrup. Optimum separation of the compounds was obtained using a C-18 Lichrospher 5 μm column with a mixture of methanol:water containing acetic acid glacial 0.5% and sodium hexane sulfonate 5 mM as mobile phase (35:65) in isocratic system at flow rate of 1 ml/min. The analysis was performed with PDA detector at 262 nm and temperature of column of 30oC. Retention time of paracetamol was 3.212 minutes, glyceryl guaiacolate was 8.430 minutes and ephedrine HCl can not be detected using this method. Resolution (Rs) between paracetamol and glyceryl guaiacolate was 13.73, respectively. A good linearity was achieved in the range of concentration from 100.2 to 300.7 mg/ml for parasetamol and between 40.4 and 121.2 mg/ml for glyceryl guaiacolate. Recoveries of parasetamol and glyceryl guaiacolate were (99.36±0.55)% and (99.71± 0.17)%, respectively. The relative standard deviation (RSD) values was less than 2% for each compounds. The methods showed good result and fulfill the validation requirements

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.KF.45/17 Rum o
Uncontrolled Keywords: Paracetamol, glyceryl guaiacolate, ephedrine HCl, HPLC, method validation, cough-cold syrup formulation
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
ANISA RUMINTANG, 051311133105UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorH. M. Yuwono, Prof. Dr. rer. nat., MS., Apt.UNSPECIFIED
ContributorAsri Darmawati, Dr., MS., Apt.UNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:40
Last Modified: 17 Jan 2018 21:19
URI: http://repository.unair.ac.id/id/eprint/65290
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