SINTESIS ETIL p-HIDROKSISINAMAT DARI REAKSI ETIL p-METOKSISINAMAT DAN PIRIDINA HIDROKLORIDA MENGGUNAKAN IRADIASI GELOMBANG MIKRO

R. M. ILMAN HAFIZH, 050911180 (2017) SINTESIS ETIL p-HIDROKSISINAMAT DARI REAKSI ETIL p-METOKSISINAMAT DAN PIRIDINA HIDROKLORIDA MENGGUNAKAN IRADIASI GELOMBANG MIKRO. Skripsi thesis, Universitas Airlangga.

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Abstract

An attempt to synthesis ethyl p-hydroxycinnamate from ethyl pmethoxycinnamate as natural starting material has been done by reacting it with pyridine hydrochloride under microwave irradiation. Ethyl p-methoxycinnamate was isolated from Kaempferia galanga L. The ether extract of result compound analyzed using TLC, resulted two new TLC spot. Then, the multi-component was separated by column chromatography and single-spot result was analyzed by spectroscopy of UV-Vis, FT/IR, and NMR. NMR spectra shown a lot of noise means that the compound was a multi-compound. GC-MS analysis was done to give a better resolution in separation. Result shown five peaks other than starting compound’s. MS spectra was analyzed and resulting demethylation was occured along with addition of hydrochloride at starting compound. Similar reaction was done with conventional heating to give the same result.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.KF.46/17 Haf s
Uncontrolled Keywords: Ethyl p-methoxycinnamate, pyridine hydrochloride, microwave assisted organic synthesis, ethyl phydroxycinnamate and identification
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
R. M. ILMAN HAFIZH, 050911180UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHadi Poerwono, Drs., Apt., M.Sc., Ph.D.UNSPECIFIED
ContributorJuni Ekowati, Dr., Apt., M.Si.UNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:41
Last Modified: 17 Jan 2018 21:20
URI: http://repository.unair.ac.id/id/eprint/65293
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