PENGARUH GUGUS FUNGSI SULFONAT PADA SINTESIS SENYAWA ASAM 4-[4-OKSO-2- FENILKUINAZOLIN-3(4H)-IL]BENZENASULFONAT MENGGUNAKAN IRADIASI GELOMBANG MIKRO

JIK AJANTIH DAMASAZIS, 051311133135 (2017) PENGARUH GUGUS FUNGSI SULFONAT PADA SINTESIS SENYAWA ASAM 4-[4-OKSO-2- FENILKUINAZOLIN-3(4H)-IL]BENZENASULFONAT MENGGUNAKAN IRADIASI GELOMBANG MIKRO. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aims to determine the effect of sulfonate group in synthesis of 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzenesulfonic acid was compared with synthesis 2,3-diphenylquinazolin-4(3H)-one. The reaction between 2-phenyl-4H-benzo[d][1,3]oxazin-4-one with aniline gave 2,3-diphenylquinazolin-4(3H)-one, while the reaction between 2- phenyl-4H-benzo[d][1,3]oxazin-4-one and sulfanilic acid gave 4-[4-oxo- 2-phenylquinazolin-3(4H)-yl]benzenesulfonic acid. The synthesize were completed by microwave irradiation in same condition, except time of synthesis that determined the completing reaction. But that reaction with aniline did not obtain 2,3-diphenylquinazolin-4(3H)-one and it was obtained 2-benzamido-N-phenylbenzamide. 2-benzamido-N-phenylbenzamide was obtained as lightweight and white powder with 70 minutes to completing the reaction, while 4-[4-oxo- 2-phenylquinazolin-3(4H)-yl]benzenesulfonic acid was obtained as lightweight and yellowish powder with 10 minutes to completing the reaction. The structure of resulted compounds were confirmed by UVVis spectrophotometer, IR spectrophotometer and 1H-NMR spectrometer. It was concluded that sulfonate group was responsible to increase reactivity and decrease the time to completing reaction in the synthesis of 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzenesulfonic acid. The time to completing reaction of synthesis 4-[4-oxo-2-phenylquinazolin-3(4H)- yl]benzenesulfonic acid was lower than the time to completing reaction of synthesis 2-benzamido-N-phenylbenzamide.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.KF.49/17 Pam p
Uncontrolled Keywords: microwave irradiation, 4-[4-oxo-2-phenylquinazolin-3(4H)- yl]benzenesulfonic acid, 2,3-diphenylquinazolin-4(3H)-one, 2-benzamido-N-phenylbenzamide, aniline, sulfanilic acid
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
JIK AJANTIH DAMASAZIS, 051311133135UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutuk Budiati, Prof., Dr., M.S., Apt.UNSPECIFIED
ContributorKholis Amalia Nofianti, M.Sc., AptUNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:42
Last Modified: 17 Jan 2018 21:23
URI: http://repository.unair.ac.id/id/eprint/65296
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