PENGARUH GUGUS NITRO TERHADAP SINTESIS 2-(2-KLOROFENIL)- 3-(4-NITROFENIL)KUINAZOLIN-4(3H)-ON DENGAN IRADIASI GELOMBANG MIKRO

SYAFI’I, 051311133166 (2017) PENGARUH GUGUS NITRO TERHADAP SINTESIS 2-(2-KLOROFENIL)- 3-(4-NITROFENIL)KUINAZOLIN-4(3H)-ON DENGAN IRADIASI GELOMBANG MIKRO. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aims to investigate the effect of nitro groups on Microwave-Assisted Synthesize Of 2-(2-Chlorophenyl)-3-(4-Nitrophenyl)Quinazolin-4(3H)-One. As comparison, also synthesize 2-(2-Chlorophenyl)-3-phenylquinazolin-4(3H)-One with microwave irradiation. The effect of nitro groups is seen from the reactivity of amine groups to substitute 2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazine-4-one under the same conditions. Based on these conditions, in 2-(2-chlorophenyl)-3-phenylquinazolin-4(3H)-one synthesis, stain 2-(2-chlorophenyl)-4H-benzo[d][1,3]oksazin-4-on missing and emerging a new stain, while in 2-(2-chlorophenyl)-3-(4-nitrophenyl) quinozolin-4(3H)-one synthesis, stain 2-(2-chlorophenyl)-4H-benzo[d][1,3] oxazine-4-one is not lost and no new stains appear. It was conclude that nitro groups responsible to reduce reactivity of amine groups to substitute 2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazine-4-one. The reaction between 2-(2-chlorophenyl)-4H-benzo [d][1,3]oxazin-4-one with aniline gave 2-chloro-N-(2-(phenylcarbamoyl)phenyl)benzamide, while reaction between 2-(2-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one with p-nitroaniline not identified yet to gave 2-(2-Chlorophenyl)-3-(4-Nitrophenyl)Quinazolin-4(3H)-One. The structure of resulted compound were confirmed by UVVis spectrophotometer, IR spectrophotometer and 1H-NMR spectrometer, and mass spectrophotometer.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.KF.53/17 Sya p
Uncontrolled Keywords: Microwave irradiation, 2-(2-chlorophenyl)-4H-benzo[d][1,3]oksazin-4-on, aniline, p-nitroaniline, 2-(2-Chlorophenyl)-3-phenylquinazolin-4(3H)-One, 2-(2-Chlorophenyl)-3-(4-Nitrophenyl)Quinazolin-4(3H)-One, 2-chloro-N-(2-(phenylcarbamoyl)phenyl)benzamide
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
SYAFI’I, 051311133166UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutuk Budiati, Prof., Dr., M.S., Apt.UNSPECIFIED
ContributorH. Achmad Syahrani, Prof., Dr., Apt., MS.UNSPECIFIED
Depositing User: Mr Binkol1 1
Date Deposited: 28 Dec 2017 19:44
Last Modified: 17 Jan 2018 21:31
URI: http://repository.unair.ac.id/id/eprint/65300
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