PENGARUH KADAR KOPOLIMER ASAM METAKRILAT TIPE L TERHADAP PROTEKSI Lactobacillus casei PADA PROSES MIKROENKAPSULASI (Metode Spray Drying Suhu Inlet 110 °C)

FIRNANDA YANA PRASTIWI, 051311133094 (2017) PENGARUH KADAR KOPOLIMER ASAM METAKRILAT TIPE L TERHADAP PROTEKSI Lactobacillus casei PADA PROSES MIKROENKAPSULASI (Metode Spray Drying Suhu Inlet 110 °C). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Probiotics are living microorganisms that provide health benefits to the host when administered in adequate quantities. One of the most widely used probiotics is Lactobacillus casei. The minimum amount of probiotics to give effect to host effectively is 106 cfu/gram. Probiotics will be damaged at gastric juice (pH 2) whereas the target of action is intestine. Microencapsulation using suitable technique and matrix was needed as an efficient methods to protect probiotics from extreme condition in gastrointestinal tract and release them in intestine as the target organ. Lactobacillus casei was made into microparticles by spray drying at 110 °C inlet temperature with two different concentration of metacrylic acid copolymer L type as the matrix. Two different concentration was named formula I for 0,5% matrix concentration and formula II for 1,0% matrix concentration. The result showed that the increase of metacrylic acid copolymer L type concentration lead the greater protection in Lactobacillus casei when microencapsulation was occurred and both formulas were significantly different (p < 0,05).

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 06-17 Pra p
Uncontrolled Keywords: Lactobacillus casei, probiotics, metacrylic acid copolymer L type, microencapsulation, spray drying, protection.
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
FIRNANDA YANA PRASTIWI, 051311133094UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorSugiyartono, Dr., MS., Apt.UNSPECIFIED
ContributorDwi Setyawan, Dr., S.Si., M.Si., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 01 Nov 2017 02:39
Last Modified: 01 Nov 2017 02:39
URI: http://repository.unair.ac.id/id/eprint/65403
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