PENGARUH KADAR KOPOLIMER ASAM METAKRILAT TIPE L SEBAGAI MATRIKS MIKROPARTIKEL TERHADAP PELEPASAN Lactobacillus casei (Metode Spray Drying Suhu Inlet 120 °C)

BARASASTI FEBIANANDA YAPUTRI, 051311133199 (2017) PENGARUH KADAR KOPOLIMER ASAM METAKRILAT TIPE L SEBAGAI MATRIKS MIKROPARTIKEL TERHADAP PELEPASAN Lactobacillus casei (Metode Spray Drying Suhu Inlet 120 °C). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microencapsulation is defined as a process in which the active ingredient is encapsulated with matrix by forming a thin film surrounding the active ingredient. The microencapsulation processes produce small particles ranging in size from 1 to 1000 μm that can provide physical barrier against adverse environmental conditions. Lactobacillus casei is used as an active ingredient which will be made into microparticles by spray drying method with 120 °C inlet temperature using methacrylic acid copolymer L type as polymer matrix which can provide protection in the stomach and released the active ingredient in intestine. The effect of methacrylic acid copolymer L type concentration on Lactobacillus casei release from microparticle determined by using three formula with 0,5%; 0,75%; and 1,50% concentration of methacrylic acid copolymer L type. Release efficiency test were performed in all formula. The result showed that release efficiency of Lactobacillus casei in microparticle probiotic decrease with increasing methacrylic acid copolymer L type concentration.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 07-17 Yap p
Uncontrolled Keywords: Microencapsulation, Lactobacillus casei, Methacrylic acid copolymer L type, Probiotic, Spray drying, Release efficiency.
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
BARASASTI FEBIANANDA YAPUTRI, 051311133199UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorWidji Soeratri, Prof. Dr., Apt., DEA.UNSPECIFIED
ContributorSugiyartono, Dr. H., Apt., MS.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 01 Nov 2017 02:44
Last Modified: 01 Nov 2017 02:44
URI: http://repository.unair.ac.id/id/eprint/65405
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